Document Detail

Association of Chlamydia trachomatis heat-shock protein 60 antibody and HLA class II DQ alleles.
MedLine Citation:
PMID:  10353888     Owner:  NLM     Status:  MEDLINE    
A total of 113 female commercial sex workers had individual alleles for HLA class II genes determined by using labeled sequence-specific oligonucleotide probes to hybridize to polymerase chain reaction products of amplified DNA. Women also had microimmunofluorescent (MIF) antibody titers to Chlamydia trachomatis elementary bodies and ELISA antibody to recombinant chlamydial heat-shock protein 60 (Chsp60) determined. Women were prospectively followed at monthly intervals over 2 years for incident C. trachomatis infection and acute pelvic inflammatory disease (PID). HLA DQA1*0401 and DQB1*0402 alleles were statistically associated with increased prevalence and amount of antibody to Chsp60 but not MIF antibody. However, these alleles did not alter the risk for chlamydial PID. The potential role that HLA DQ may play in chlamydial disease pathogenesis requires further study.
L K Gaur; R W Peeling; M Cheang; J Kimani; J Bwayo; F Plummer; R C Brunham
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  180     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-07-29     Completed Date:  1999-07-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  234-7     Citation Subset:  AIM; IM    
Immunogenetics, Puget Sound Blood Centre, Seattle, WA 98104, USA.
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MeSH Terms
Antibodies, Bacterial / blood
Bacterial Proteins / immunology
Chaperonin 60 / immunology*
Chlamydia Infections / etiology,  immunology*
Chlamydia trachomatis / immunology*
HLA-DQ Antigens / genetics*
Pelvic Inflammatory Disease / etiology,  immunology*
Grant Support
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Proteins; 0/Chaperonin 60; 0/HLA-DQ Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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