| Association of Cervical Cytology and HPV DNA Status During Pregnancy With Placental Abnormalities and Preterm Birth. | |
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MedLine Citation:
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PMID: 21757599 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The clinical implications of abnormal cervical cytology during pregnancy are unclear. Therefore, we performed the present study to determine the role of cervical cytologic screening during pregnancy in association with placental abnormalities and preterm birth. A review of 2,480 cases during 11 years revealed significant correlation of reactive, infectious, atypical, and dysplastic cytologic changes during pregnancy with abnormal placental findings. Also, all but dysplastic cytologic changes were significantly associated with preterm birth. Furthermore, we observed significant association of the presence of high-risk human papillomavirus (HPV) DNA with preterm birth and placental abnormalities. These findings indicate that cervical infection of HPV is a risk factor for preterm birth and that cervical cytology is an effective tool for screening women for infection and inflammation during pregnancy and predicting pregnancy outcome. |
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Authors:
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Zhuang Zuo; Suman Goel; J Elliot Carter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of clinical pathology Volume: 136 ISSN: 1943-7722 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 260-5 Citation Subset: AIM; IM |
Affiliation:
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Molecular Diagnostics Laboratory, Dept of Hematopathology, Unit 149, The University of Texas M.D. Anderson Cancer Center, 8515 Fannin Street, Houston, TX 77054. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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