| Association of central systolic blood pressure with intracerebral small vessel disease in Japanese. | |
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MedLine Citation:
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PMID: 20339355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Recent studies have reported the association between advanced arterial stiffness and brain small vessel diseases (SVDs). Two possible hemodynamic mechanisms, increases in central blood pressure (BP) and pulsatile flow load to the brain, have been speculated to link arterial stiffness and SVD. The carotid flow augmentation index (AI) has been proposed as an index of pulsatile flow to the brain. We compared its association with brain SVD with that of central BP in a general population. METHODS: Subjects were 500 individuals free from symptomatic cardiovascular diseases with a mean age of 66.9 +/- 8.4 years. Brachial-ankle pulse wave velocity (baPWV) was measured as an index of arterial stiffness. Carotid flow AI was obtained by Doppler ultrasonography. The presence of silent cerebral lacunar infarcts (SCI) was determined as a manifestation of SVD by 3-tesla magnetic resonance imaging (MRI). Second peak radial systolic BP (SBP2) and pulse pressure (PP2) were used as estimates of central BP. RESULTS: baPWV was significantly associated with radial BP2 (r = 0.55, P < 0.0001) but not with carotid flow AI (r = 0.03, P = 0.51). Radial BPs and baPWV, but not flow AI, were significantly higher in subjects with SCI. Radial SBP2 had higher odds ratio for the presence of SCI than brachial SBP, PP, and radial PP2. Logistic regression analysis showed that radial SBP2, but not flow AI, was independently related to the presence of SCI. CONCLUSION: These findings indicate that the SBP2, an estimate of central SBP, is significantly associated with the presence of SVD in an apparently healthy general population. |
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Authors:
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Namiko Ochi; Katsuhiko Kohara; Yasuharu Tabara; Tokihisa Nagai; Tomoko Kido; Eri Uetani; Masayuki Ochi; Michiya Igase; Tetsuro Miki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-25 |
Journal Detail:
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Title: American journal of hypertension Volume: 23 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2010-11-03 Revised Date: 2011-06-30 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 889-94 Citation Subset: IM |
Affiliation:
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Department of Geriatric Medicine, Ehime Graduate School of Medicine, Toon City, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Ankle Brachial Index Asian Continental Ancestry Group Blood Flow Velocity / physiology Blood Pressure / physiology* Carotid Arteries / physiology* Cerebral Infarction / diagnosis* Cerebrovascular Circulation* Humans Logistic Models Magnetic Resonance Imaging Middle Aged Pulsatile Flow Vascular Resistance |
| Comments/Corrections | |
Comment In:
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Am J Hypertens. 2010 Sep;23(9):932; author reply 933
[PMID:
20733567
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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