| Association of central aortic pressures indexes with development of diabetes mellitus in essential hypertension. | |
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MedLine Citation:
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PMID: 20634800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Diabetes mellitus (DM) and hypertension (HT) frequently coexist. Increased central aortic pressures indexes are associated with HT; however, possible associations of these indexes with future development of DM have never been studied in HT. METHODS: We recruited 178 patients with uncomplicated nondiabetic HT in this study. Baseline glucose, insulin, lipid profiles, and central aortic pressure indexes obtained using applanation tonometry were measured at the beginning of the study. Patients were followed for new-onset DM. RESULTS: After a mean follow-up period of 31 ± 12 months, 22 patients (12.4%) developed new-onset DM. In multivariate regression analyses adjusted for age, sex, and mean blood pressure (BP) in model 1, we found that central systolic BP (CSBP; hazard ratio 1.24, 95% CI 1.10-1.41, P < 0.001), and augmentation index (AIx) corrected at heart rate 75/min (AIx(75); hazard ratio 1.58, 95% CI 1.11-1.58, P < 0.05) were independent predictors for new-onset DM. After adjustment for age, sex, mean BP, glucose concentration, and β-blocker use in model 2, we found that CSBP (hazard ratio 1.36, 95% CI 1.19-1.55, P < 0.001) and AIx(75) (hazard ratio 1.71, 95% CI 1.16-2.52, P < 0.01) were independent predictors for new-onset DM. CONCLUSIONS: CSBP and AIx(75) were independent factors for future DM in essential hypertensive patients. Increased central pressure indexes were associated with risk of DM in essential hypertension. |
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Authors:
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Ju-Yi Chen; Chang-Hua Chou; Yungling Leo Lee; Wei-Chuan Tsai; Chih-Chan Lin; Yao-Yi Huang; Jyh-Hong Chen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-15 |
Journal Detail:
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Title: American journal of hypertension Volume: 23 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2011-01-07 Revised Date: 2011-06-30 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 1069-73 Citation Subset: IM |
Affiliation:
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National Cheng Kung University, Tainan, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use Adult Aorta / physiology Blood Chemical Analysis Blood Glucose / metabolism Blood Pressure / physiology* Carotid Arteries / physiology Central Venous Pressure / physiology Diabetes Mellitus, Type 2 / complications* Female Follow-Up Studies Heart Rate / physiology Humans Hypertension / complications*, drug therapy Insulin Resistance Male Middle Aged Radial Artery / physiology Regional Blood Flow / physiology Regression Analysis Survival Analysis |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Blood Glucose |
| Comments/Corrections | |
Comment In:
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Am J Hypertens. 2010 Oct;23(10):1047-8
[PMID:
20852596
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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