Document Detail


Association of CYP17 gene polymorphism and rheumatoid arthritis in Chinese patients in central Taiwan.
MedLine Citation:
PMID:  15235815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated whether there is an association between polymorphism of the CYP17 gene and rheumatoid arthritis in Chinese patients in central Taiwan. Genomic DNA was extracted from the peripheral blood of 146 female and 47 male RA patients, as well as from 42 female and 59 male control subjects; restriction fragment length polymorphism (defined as the A1 and A2 alleles) was then determined. Clinical variables such as rheumatoid factor positivity, extra-articular manifestations, and joint erosion were also investigated for the RA patients. We found that more male RA patients had the A1 allele (P=0.019) and fewer female RA patients the A2 allele than control subjects (P=0.048). In male RA patients, A1 carriers showed more extra-articular manifestations (P=0.048). In female patients, a significant decrease in A2 carriers mainly occurred in the later-onset age group (P=0.024). This study suggests that the A2 allele may significantly decrease the overall risk of developing RA. In women, the protective effect of A2 mainly affects the older age group. In men, the clinical severity of RA may decrease in patients with the A2/A2 genotype.
Authors:
Sui-Foon Lo; Chung-Ming Huang; Hsiu-Chen Lin; Chang-Hai Tsai; Fuu-Jen Tsai
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Publication Detail:
Type:  Journal Article     Date:  2004-07-03
Journal Detail:
Title:  Rheumatology international     Volume:  25     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-28     Completed Date:  2006-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  580-4     Citation Subset:  IM    
Affiliation:
Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Alleles
Arthritis, Rheumatoid / ethnology,  genetics*
Asian Continental Ancestry Group / genetics*
Female
Humans
Male
Middle Aged
Polymorphism, Genetic
Steroid 17-alpha-Hydroxylase / genetics*
Taiwan / ethnology
Chemical
Reg. No./Substance:
EC 1.14.99.9/Steroid 17-alpha-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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