| Association of CD28 IVS3 +17T/C polymorphism with soluble CD28 in rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 21508506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology in which inflammatory pathology involves T cell activation and the CD28 costimulatory molecule involved in T cell presentation. The gene includes the CD28 IVS3 +17T/C polymorphism that could be associated with susceptibility to RA whereas the soluble concentrations of CD28 (sCD28) could be related to clinical activity. METHODS: We investigated the CD28 IVS3 +17T/C polymorphism in 200 RA patients and 200 healthy subjects (HS). Furthermore, we quantified the sCD28 concentrations in 77 samples of each group. We applied indexes focused to determine the activity and disability (DAS28 and Spanish HAQ-DI, respectively) in RA patients. RESULTS: RA patients had significantly higher frequencies of the CD28 T allele compared to HS (p = 0.032 OR = 1.59, C.I. 1.02-2.49). In addition, the IVS3 +17 T/T genotype frequency was also increased in RA vs. HS (p = 0.026). The RA patients showed higher sCD28 serum levels than HS (p = 0.001). Carriers of the T/T genotype in RA patients showed higher sCD28 levels than C/C carriers (p =0.047). In addition, a correlation between sCD28 and Spanish HAQ-DI (correlation, 0.272; p =0.016), was found. CONCLUSION: The T allele in CD28 IVS3 +17T/C polymorphism is associated with a susceptibility to RA in Western Mexico. In addition, increased sCD28 levels are related to T/T genotype in RA patients. |
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Authors:
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I Y Ledezma-Lozano; J J Padilla-Martínez; S D Leyva-Torres; I Parra-Rojas; M G Ramírez-Dueñas; Ana Laura Pereira-Suárez; H Rangel-Villalobos; S L Ruiz-Quezada; P E Sánchez-Hernández; J F Muñoz-Valle |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Disease markers Volume: 30 ISSN: 1875-8630 ISO Abbreviation: Dis. Markers Publication Date: 2011 |
Date Detail:
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Created Date: 2011-04-21 Completed Date: 2011-08-05 Revised Date: 2011-08-10 |
Medline Journal Info:
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Nlm Unique ID: 8604127 Medline TA: Dis Markers Country: Netherlands |
Other Details:
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Languages: eng Pagination: 25-9 Citation Subset: IM |
Affiliation:
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Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD28 / blood, genetics* Arthritis, Rheumatoid / genetics* Case-Control Studies Female Gene Frequency Genetic Association Studies Genotype Humans Introns Male Mexico Middle Aged Polymorphism, Single Nucleotide* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD28 |
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