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Association of CD28 IVS3 +17T/C polymorphism with soluble CD28 in rheumatoid arthritis.
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MedLine Citation:
PMID:  21508506     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology in which inflammatory pathology involves T cell activation and the CD28 costimulatory molecule involved in T cell presentation. The gene includes the CD28 IVS3 +17T/C polymorphism that could be associated with susceptibility to RA whereas the soluble concentrations of CD28 (sCD28) could be related to clinical activity.
METHODS: We investigated the CD28 IVS3 +17T/C polymorphism in 200 RA patients and 200 healthy subjects (HS). Furthermore, we quantified the sCD28 concentrations in 77 samples of each group. We applied indexes focused to determine the activity and disability (DAS28 and Spanish HAQ-DI, respectively) in RA patients.
RESULTS: RA patients had significantly higher frequencies of the CD28 T allele compared to HS (p = 0.032 OR = 1.59, C.I. 1.02-2.49). In addition, the IVS3 +17 T/T genotype frequency was also increased in RA vs. HS (p = 0.026). The RA patients showed higher sCD28 serum levels than HS (p = 0.001). Carriers of the T/T genotype in RA patients showed higher sCD28 levels than C/C carriers (p =0.047). In addition, a correlation between sCD28 and Spanish HAQ-DI (correlation, 0.272; p =0.016), was found.
CONCLUSION: The T allele in CD28 IVS3 +17T/C polymorphism is associated with a susceptibility to RA in Western Mexico. In addition, increased sCD28 levels are related to T/T genotype in RA patients.
I Y Ledezma-Lozano; J J Padilla-Martínez; S D Leyva-Torres; I Parra-Rojas; M G Ramírez-Dueñas; Ana Laura Pereira-Suárez; H Rangel-Villalobos; S L Ruiz-Quezada; P E Sánchez-Hernández; J F Muñoz-Valle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Disease markers     Volume:  30     ISSN:  1875-8630     ISO Abbreviation:  Dis. Markers     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-21     Completed Date:  2011-08-05     Revised Date:  2013-12-02    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  25-9     Citation Subset:  IM    
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MeSH Terms
Antigens, CD28 / blood,  genetics*
Arthritis, Rheumatoid / genetics*
Case-Control Studies
Gene Frequency
Genetic Association Studies
Middle Aged
Polymorphism, Single Nucleotide*
Young Adult
Reg. No./Substance:
0/Antigens, CD28

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
ISSN: 0278-0240
ISSN: 1875-8630
Publisher: IOS Press
Article Information
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Copyright © 2011 Hindawi Publishing Corporation.
Received Day: 14 Month: 4 Year: 2011
Accepted Day: 14 Month: 4 Year: 2011
Print publication date: Year: 2011
Electronic publication date: Day: 20 Month: 4 Year: 2011
Volume: 30 Issue: 1
First Page: 25 Last Page: 29
PubMed Id: 21508506
ID: 3825076
Article Id: 620849
DOI: 10.3233/DMA-2011-0760

Association of CD28 IVS3 +17T/C Polymorphism with Soluble CD28 in Rheumatoid Arthritis
I. Y. Ledezma-Lozano1
J. J. Padilla-Martínez1
S. D. Leyva-Torres2
I. Parra-Rojas3
M. G. Ramírez-Dueñas4
Ana Laura Pereira-Suárez4
H. Rangel-Villalobos5
S. L. Ruiz-Quezada6
P. E. Sánchez-Hernández4
J. F. Muñoz-Valle1*
1Departamento de Biología Molecular y Genómica. Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraJaliscoMéxico
2Department of Rheumatology. Hospital "Valentín Gómez-Farías ISSSTE"ZapopanJaliscoMéxico
3Unidad Académica de Ciencias Químico-BiológicasUniversidad Autónoma de GuerreroChilpancingoGuerreroMéxico
4Laboratorio de Inmunología. Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraJaliscoMéxico
5Instituto de Investigación en Genética Molecular. Centro Universitario de la CiénegaUniversidad de Guadalajara; OcotlánJaliscoMéxico
6Laboratorio de Biología MolecularCentro Universitario de Ciencias Exactas e IngenieríasUniversidad de Guadalajara; GuadalalajaraJaliscoMéxico
Correspondence: *J. F. Muñoz-Valle:

Article Categories:
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Keywords: CD28, IVS3 +17T/C, polymorphism, rheumatoid arthritis, sCD28.

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