| Association of CD1A +622 T/C, +737 G/C and CD1E +6129 A/G genes polymorphisms with multiple sclerosis. | |
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MedLine Citation:
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PMID: 20954848 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Antibodies and specific T cells to glycolipids have been found in MS patients. CD1 molecules are involved in presentation of lipid antigens to T-cells. Therefore, functional polymorphisms in two CD1 genes (+622 T/C and +737 G/C in CD1A along with +6129 A/G in CD1E) might be associated with susceptibility to MS. First, 351 MS patients and 342 controls were enrolled in this study. Allele-specific oligonucleotide polymerase chain reaction and PCR-RFLP methods were used for genotyping. The frequency of CD1A genotypes was not different between cases and controls. However, investigating females, the frequency of CD1A*01 allele was significantly higher in patients with PP-MS compared to controls (p = 0.028) as well as to RR-MS and SP-MS (p = 0.042 and 0.021, respectively). The distribution of CD1E +6129 A allele (CD1E*01) and CD1E*01/01 genotype is more frequent in normal controls in comparison with MS patients (p = 0.001 and p = 0.0003, respectively). In addition, after categorization of study groups according to disease types, differences between alleles and genotypes of CD1E gene polymorphism remained significant for RR-MS patients compared to those of normal controls (p = 0.0001 and p = 0.0003, respectively). CD1E and CD1A genes may be involved in networks which determine susceptibility to RR-MS and PP-MS, respectively. |
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Authors:
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Azam Jamshidian; Ali-Reza Nikseresht; Mahmood Vessal; Eskandar Kamali-Sarvestani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Immunological investigations Volume: 39 ISSN: 1532-4311 ISO Abbreviation: Immunol. Invest. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-10-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8504629 Medline TA: Immunol Invest Country: England |
Other Details:
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Languages: eng Pagination: 874-89 Citation Subset: IM |
Affiliation:
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Department of Immunology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz-Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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