Document Detail


Association of CAG repeat loci on chromosome 22 with schizophrenia and bipolar disorder.
MedLine Citation:
PMID:  11673798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chromosome 22 has been implicated in schizophrenia and bipolar disorder in a number of linkage, association and cytogenetic studies. Recent evidence has also implicated CAG repeat tract expansion in these diseases. In order to explore the involvement of CAG repeats on chromosome 22 in these diseases, we have created an integrated map of all CAG repeats > or =5 on this chromosome together with microsatellite markers associated with these diseases using the recently completed nucleotide sequence of chromosome 22. Of the 52 CAG repeat loci identified in this manner, four of the longest repeat stretches in regions previously implicated by linkage analyses were chosen for further study. Three of the four repeat containing loci, were found in the coding region with the CAG repeats coding for glutamine and were expressed in the brain. All the loci studied showed varying degrees of polymorphism with one of the loci exhibiting two alleles of 7 and 8 CAG repeats. The 8-repeat allele at this locus was significantly overrepresented in both schizophrenia and bipolar patient groups when compared to ethnically matched controls, while alleles at the other three loci did not show any such difference. The repeat lies within a gene which shows homology to an androgen receptor related apoptosis protein in rat. We have also identified other candidate genes in the vicinity of this locus. Our results suggest that the repeats within this gene or other genes in the vicinity of this locus are likely to be implicated in bipolar disorder and schizophrenia.
Authors:
Q Saleem; D Dash; C Gandhi; A Kishore; V Benegal; T Sherrin; O Mukherjee; S Jain; S K Brahmachari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular psychiatry     Volume:  6     ISSN:  1359-4184     ISO Abbreviation:  Mol. Psychiatry     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-23     Completed Date:  2002-01-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9607835     Medline TA:  Mol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  694-700     Citation Subset:  IM    
Affiliation:
Functional Genomics Unit, Centre for Biochemical Technology (CSIR), Mall Rd, Delhi University Campus, Delhi 110 007, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticipation, Genetic
Bipolar Disorder / genetics*
Brain Chemistry / genetics
Chromosomes, Human, Pair 22*
Female
Gene Frequency
Genotype
Humans
Male
Microsatellite Repeats
Schizophrenia / genetics*
Trinucleotide Repeats*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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