| Association of the C677T MTHFR polymorphism with homocysteine, ox-LDL levels, and thiolactonase activities in the severity of coronary syndrome. | |
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MedLine Citation:
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PMID: 20530057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary artery diseases (CAD) are influenced by multiple genes of modest effect as the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, related to MTHFR activity and total plasma homocysteine (tHcy) concentration. This study was designed to evaluate tHcy, oxidized low-density lipoprotein (LDL) (ox-LDL), high-sensibility C-reactive protein (Hs CRP) levels, and homocysteine thiolactonase (HTase) activities as new risk factors for CAD and to investigate an association between MTHFR polymorphism tHcy concentrations and coronary syndrome severity. Our results showed significantly higher levels of tHcy and ox-LDL in patients associated with lower HTase activities. These levels increased proportionally to disease severity. Total plasma Hcy levels were negatively correlated to HTase activities in patients where the TT genotype was significantly more frequent. In a multivariate analysis, tHcy level was the only independent factor affecting the coronary syndrome severity. High tHcy levels are associated with coronary syndrome severity and may be explained either by the elevated prevalence of TT genotype or by the diminished HTase activities. |
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Authors:
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Nadia Koubaa; Amel Nakbi; Sonia Hammami; Sounira Mehri; Nabil Attia; Mohamed Ben Farhat; Mohamed Hammami |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-07 |
Journal Detail:
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Title: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis Volume: 16 ISSN: 1938-2723 ISO Abbreviation: Clin. Appl. Thromb. Hemost. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-20 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508125 Medline TA: Clin Appl Thromb Hemost Country: United States |
Other Details:
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Languages: eng Pagination: 515-21 Citation Subset: IM |
Affiliation:
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Laboratory of Biochemistry, UR Human Nutrition and Metabolic Disorders, Faculty of Medicine, Monastir, Tunisia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged C-Reactive Protein / metabolism Carboxylic Ester Hydrolases / blood* Cohort Studies Coronary Artery Disease / blood*, enzymology, genetics* Female Genotype Homocysteine / blood* Humans Lipoproteins, LDL / blood* Male Methylenetetrahydrofolate Reductase (NADPH2) / genetics* Polymorphism, Genetic Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; 454-28-4/Homocysteine; 9007-41-4/C-Reactive Protein; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2); EC 3.1.1.-/Carboxylic Ester Hydrolases; EC 3.1.1.-/homocysteine-thiolactonase, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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