| Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis. | |
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MedLine Citation:
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PMID: 17143166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The CYP11B2 gene (CYP11B2) encoding aldosterone synthase has been associated with essential hypertension and some, but not all, studies have reported that the C-344T variant may influence the risk of the disease. OBJECTIVE: We performed a systematic review of the literature by means of a meta-analysis to evaluate the influence of the C-344T CYP11B2 polymorphism on arterial hypertension and intermediate phenotypes. METHODS: From 485 reports, we included 42 observational studies, case-control and cohort at baseline. Fixed and random effect models were used to pool data from individual studies. RESULTS: From 19 heterogeneous studies including 5343 essential hypertensive and 5882 control subjects, we found a significant association between hypertension and the C-344T variant in fixed but not in random effect models [for homozygous CC: odds ratio (OR), 0.834; 95% confidence interval (CI), 0.760-0.914; P < 0.0001, n = 11 225]. Besides, homozygous CC subjects had lower plasma renin activity (D, -0.161; 95% CI, -0.279 to -0.043; P < 0.01, n = 1428) but no difference in plasma aldosterone levels (D, -0.006; 95% CI, -0.081 to 0.07; P = 0.88, n = 2872). Limiting the quantitative analysis of blood pressure to 13 studies including only untreated individuals, no significant association was found for systolic arterial blood pressure (D, 0.042; 95% CI, -0.057 to 0.141; P = 0.41, n = 1775) and diastolic arterial blood pressure (D, 0.026; 95% CI, -0.073 to 0.125; P = 0.61, n = 1775). CONCLUSION: Homozygous individuals for the -344C CYP11B2 allele are at 17% lower risk of hypertension with respect to homozygous TT subjects. |
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Authors:
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Silvia Sookoian; Tomas Fernández Gianotti; Claudio Daniel González; Carlos Jose Pirola |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of hypertension Volume: 25 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-04 Completed Date: 2007-03-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 5-13 Citation Subset: IM |
Affiliation:
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Cardiología Molecular, Instituto de Investigaciones Medicas, A. Lanari, Facultad de Medicina, Universidad de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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blood Aldosterone Synthase / genetics* Blood Pressure Case-Control Studies Cohort Studies Cross-Sectional Studies Cytosine Gene Frequency Genetic Predisposition to Disease Heterozygote Homozygote Humans Hypertension / blood, enzymology, genetics*, physiopathology Odds Ratio Phenotype Polymorphism, Single Nucleotide* Renin / blood Risk Assessment Risk Factors Thymine |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; 65-71-4/Thymine; 71-30-7/Cytosine; EC 1.14.15.4/Aldosterone Synthase; EC 3.4.23.15/Renin |
| Comments/Corrections | |
Comment In:
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J Hypertens. 2007 Jan;25(1):37-9
[PMID:
17143169
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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