Document Detail


Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis.
MedLine Citation:
PMID:  17143166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The CYP11B2 gene (CYP11B2) encoding aldosterone synthase has been associated with essential hypertension and some, but not all, studies have reported that the C-344T variant may influence the risk of the disease. OBJECTIVE: We performed a systematic review of the literature by means of a meta-analysis to evaluate the influence of the C-344T CYP11B2 polymorphism on arterial hypertension and intermediate phenotypes. METHODS: From 485 reports, we included 42 observational studies, case-control and cohort at baseline. Fixed and random effect models were used to pool data from individual studies. RESULTS: From 19 heterogeneous studies including 5343 essential hypertensive and 5882 control subjects, we found a significant association between hypertension and the C-344T variant in fixed but not in random effect models [for homozygous CC: odds ratio (OR), 0.834; 95% confidence interval (CI), 0.760-0.914; P < 0.0001, n = 11 225]. Besides, homozygous CC subjects had lower plasma renin activity (D, -0.161; 95% CI, -0.279 to -0.043; P < 0.01, n = 1428) but no difference in plasma aldosterone levels (D, -0.006; 95% CI, -0.081 to 0.07; P = 0.88, n = 2872). Limiting the quantitative analysis of blood pressure to 13 studies including only untreated individuals, no significant association was found for systolic arterial blood pressure (D, 0.042; 95% CI, -0.057 to 0.141; P = 0.41, n = 1775) and diastolic arterial blood pressure (D, 0.026; 95% CI, -0.073 to 0.125; P = 0.61, n = 1775). CONCLUSION: Homozygous individuals for the -344C CYP11B2 allele are at 17% lower risk of hypertension with respect to homozygous TT subjects.
Authors:
Silvia Sookoian; Tomas Fernández Gianotti; Claudio Daniel González; Carlos Jose Pirola
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of hypertension     Volume:  25     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-04     Completed Date:  2007-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  5-13     Citation Subset:  IM    
Affiliation:
Cardiología Molecular, Instituto de Investigaciones Medicas, A. Lanari, Facultad de Medicina, Universidad de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Aldosterone / blood
Aldosterone Synthase / genetics*
Blood Pressure
Case-Control Studies
Cohort Studies
Cross-Sectional Studies
Cytosine
Gene Frequency
Genetic Predisposition to Disease
Heterozygote
Homozygote
Humans
Hypertension / blood,  enzymology,  genetics*,  physiopathology
Odds Ratio
Phenotype
Polymorphism, Single Nucleotide*
Renin / blood
Risk Assessment
Risk Factors
Thymine
Chemical
Reg. No./Substance:
52-39-1/Aldosterone; 65-71-4/Thymine; 71-30-7/Cytosine; EC 1.14.15.4/Aldosterone Synthase; EC 3.4.23.15/Renin
Comments/Corrections
Comment In:
J Hypertens. 2007 Jan;25(1):37-9   [PMID:  17143169 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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