Document Detail


The Association of Body Mass Index with Serum Angiogenic Markers in Normal and Abnormal Pregnancies.
MedLine Citation:
PMID:  24631439     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: As obesity is a risk factor for placental dysfunction, we hypothesized that maternal body mass index (BMI) would be associated with alterations in serum angiogenic markers.
STUDY DESIGN: We included 2399 singleton pregnancies with and without placental dysfunction in a prospective longitudinal cohort study of angiogenic markers. We modeled the relationship between categorical and continuous BMI, sFlt-1 and PlGF over gestation, stratified by pregnancy outcome.
RESULTS: In women with normal pregnancies, higher BMI was associated with lower sFlt-1 values across gestation (p<0.0001), lower PlGF in the second and third trimester (p<0.0001), and rate of change in PlGF (p<0.0001). Similar relationships were seen between maternal BMI, sFlt-1 (p<0.0001) and PlGF (p=0.0005) in women with clinically evident placental dysfunction. Conclusions: sFlt-1 value is inversely associated with maternal BMI. The pattern of change in PlGF is also dependent on maternal BMI, indicating that obese women may have abnormalities in angiogenesis near term.
Authors:
Chloe A Zera; Ellen W Seely; Louise E Wilkins-Haug; Kee-Hak Lim; Samuel I Parry; Thomas F McElrath
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-11
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  -     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Mosby, Inc. All rights reserved.
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