| Association Between a Thyroid Hormone Receptor-α Gene Polymorphism and Blood Pressure but Not With Coronary Heart Disease Risk. | |
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MedLine Citation:
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PMID: 21654857 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BackgroundThyroid hormones (THs) exert multiple biological roles including effects on the cardiovascular system (lipid profile, blood pressure (BP) and cardiac output). The lipid-lowering actions of TH are mediated by the TH receptor-β whereas the mechanisms explaining the BP variations concomitant with the thyroid disorders are less understood. As the TH receptor-α (TR-α) has been associated with many of TH actions on the cardiovascular system in mice models, we hypothesized that it could be involved in the latter. We thus tested whether polymorphisms in TR-α (THRA gene) could be associated with BP level variation. Secondarily, we tested for association with coronary heart disease (CHD) risk.MethodsWe analyzed the associations between five THRA polymorphisms and (i) BP level in two population-based studies (MONICA Lille n = 1,155; MONICA Toulouse n = 1,170) and (ii) the risk of CHD in two case-control studies (Lille CHD n = 558 cases/568 controls; PRIME n = 527 cases/584 controls).ResultsIndividuals carrying the rs939348 T allele had higher systolic BP (~+1.3 mm Hg) than CC individuals in both the MONICA Lille (P = 0.02) and Toulouse (P = 0.03) studies. The odds ratio (OR) for hypertension was 1.25 (P = 0.02) in the combined sample. Concerning the CHD risk, no significant association could be detected.ConclusionsFor the first time, our study showed associations between the THRA rs939348 polymorphism and systolic BP and the risk of hypertension but not with CHD, although we admit that the statistical power available to study any relationship with CHD was very limited. Further larger association studies are needed to confirm our findings.American Journal of Hypertension (2011). doi:10.1038/ajh.2011.94. |
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Authors:
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Louisa Goumidi; Karine Gauthier; Vanessa Legry; Thérèse Hèrvée Mayi; Alexia Houzet; Dominique Cottel; Michèle Montaye; Carole Proust; Frank Kee; Jean Ferrières; Dominique Arveiler; Pierre Ducimetière; Bart Staels; Jean Dallongeville; Giulia Chinetti; Frédéric Flamant; Philippe Amouyel; Aline Meirhaeghe |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-09 |
Journal Detail:
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Title: American journal of hypertension Volume: - ISSN: 1879-1905 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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INSERM, U744; Institut Pasteur de Lille, Univ Lille Nord de France, Lille, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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