| Association Between Single-Nucleotide Polymorphisms in Pre-miRNAs and the Risk of Asthma in a Chinese Population. | |
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MedLine Citation:
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PMID: 21663520 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Single-nucleotide polymorphisms (SNPs) in pre-miRNAs may alter microRNA (miRNA) expression levels or processing and contribute to susceptibility to a wide range of diseases. We investigated the correlation between four SNPs (rs11614913, rs3746444, rs2910164, and rs229283) in pre-miRNAs and the risk of asthma in 220 asthma patients and 540 controls using polymerase chain reaction-restriction fragment length polymorphism methodology and DNA-sequencing. There were significant differences in the genotype and allelic distribution of rs2910164G/C and rs2292832C/T polymorphisms among cases and controls. The CC genotype and C allele of rs2910164G/C were significantly associated with a decreased risk of asthma (CC vs. GG, odds ratio [OR] = 0.51, 95% confidence interval [CI]: 0.31-0.82; C vs. G, OR = 0.74, 95% CI: 0.59-0.93). Similarly, the TT genotype and T allele of rs2292832C/T were significantly associated with a decreased risk of asthma (TT vs. CC, OR = 0.56, 95% CI: 0.33-0.95; T vs. C, OR = 0.71, 95% CI: 0.53-0.95). However, no significant association between the other two polymorphisms (i.e., rs11614913C/T and rs3746444C/T) and the risk of asthma was observed. Our data indicate that rs2910164G/C and rs2292832C/T may play a role in the development of asthma. |
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Authors:
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Xiao-Wei Su; Yan Yang; Mei-Li Lv; Li-Juan Li; Wei Dong; Miao-Liao; Lin-Bo Gao; Hai-Bo Luo; Yun-Liu; Rui-Juan Cong; Wei-Bo Liang; Ying-Bi Li |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-11 |
Journal Detail:
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Title: DNA and cell biology Volume: - ISSN: 1557-7430 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9004522 Medline TA: DNA Cell Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University , Chengdu, Sichuan, China . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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