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The Association Between Shortened Leukocyte Telomere Length and Cardio-Metabolic Outcomes: A Systematic Review and Meta-Analysis.
MedLine Citation:
PMID:  25406241     Owner:  NLM     Status:  Publisher    
BACKGROUND: -Telomeres are repetitive, gene-poor regions that cap the ends of DNA and help maintain chromosomal integrity. Their shortening is caused by inflammation and oxidative stress within the cellular environment and ultimately leads to cellular senescence. Shortened leukocyte telomere length (LTL) is hypothesized to be a novel biomarker for age and age-related diseases, yet reports on its association with cardio-metabolic outcomes in the literature are conflicting.
METHODS AND RESULTS: -MEDLINE (1966-present), and EMBASE (1980-present) were last searched on September 9(th) 2013. Reference lists of retrieved citations were hand searched for relevant studies. No restrictions were placed on sample size, language, or publication type or date. 15 Cohort and 12 case-control studies reporting the association between LTL and stroke, myocardial infarction, and type 2 diabetes were independently selected for inclusion by two reviewers. Data extraction and risk of bias assessment were completed independently by two reviewers using pre-defined criteria. Studies were pooled using the generic inverse variance method and both fixed and random effects models. A 1-standard deviation decrease in LTL was significantly associated with stroke (OR=1.21, 95% CI=1.06-1.37; I(2)=61%), myocardial infarction (OR=1.24, 95% CI=1.04-1.47; I(2)=68%), and type 2 diabetes (OR=1.37, 95% CI=1.10-1.72; I(2)=91%). Stratification by measurement technique, study design, study size, and ethnicity explained heterogeneity in certain cardio-metabolic outcomes.
CONCLUSIONS: -Shortened LTL demonstrates a significant association with stroke, myocardial infarction, and type 2 diabetes. Larger, well-designed studies are needed to confirm these findings and explore sources of heterogeneity.
Matthew J J D'Mello; Stephanie A Ross; Matthias Briel; Sonia S Anand; Hertzel Gerstein; Guillaume Paré
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-18
Journal Detail:
Title:  Circulation. Cardiovascular genetics     Volume:  -     ISSN:  1942-3268     ISO Abbreviation:  Circ Cardiovasc Genet     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-19     Completed Date:  -     Revised Date:  2014-11-20    
Medline Journal Info:
Nlm Unique ID:  101489144     Medline TA:  Circ Cardiovasc Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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