Document Detail


Association between rates of binocular visual field loss and vision-related quality of life in patients with glaucoma.
MedLine Citation:
PMID:  23450425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IMPORTANCE: It is reasonable to hypothesize that for 2 patients with similar degrees of integrated binocular visual field (BVF) loss, the patient with a history of faster disease progression will report worse vision-related quality of life (VRQOL) than the patient with slowly progressing damage. However, to our knowledge, this hypothesis has not been investigated in the literature.
OBJECTIVE: To evaluate the association between binocular rates of visual field change and VRQOL in patients with glaucoma. DESIGN Observational cohort study.
SETTING: Patients were recruited from the Diagnostic Innovations in Glaucoma Study and the African Descent and Glaucoma Evaluation Study.
PARTICIPANTS: The study included 796 eyes of 398 patients with diagnosed or suspected glaucoma followed up from October 1, 1998, until January 31, 2012, for a mean (SD) of 7.3 (2.0) years.
MAIN OUTCOME MEASURES: The VRQOL was evaluated using the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) at the last follow-up visit. The NEI VFQ-25 was completed for all patients during the period extending from December 1, 2009, through January 31, 2012. Integrated BVFs were calculated from the monocular fields of each patient. Linear regression of mean deviation values was used to evaluate rates of BVF change during the follow-up period. Logistic regression models were used to investigate the association between abnormal VRQOL and rates of BVF change, while adjusting for potentially confounding socioeconomic and demographic variables.
RESULTS: Thirty-two patients (8.0%) had abnormal VRQOL as determined by the results of the NEI VFQ-25. Patients with abnormal VRQOL had significantly faster rates of BVF change than those with normal VRQOL (-0.18 vs -0.06 dB/y; P < .001). Rates of BVF change were significantly associated with abnormality in VRQOL (odds ratio = 1.31 per 0.1 dB/y faster; P = .04), after adjustment for confounding variables.
CONCLUSIONS AND RELEVANCE: Patients with faster rates of BVF change were at higher risk of reporting abnormal VRQOL. Assessment of rates of BVF change may provide useful information in determining risk of functional impairment in glaucoma.
Authors:
Renato Lisboa; Yeoun Sook Chun; Linda M Zangwill; Robert N Weinreb; Peter N Rosen; Jeffrey M Liebmann; Christopher A Girkin; Felipe A Medeiros
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JAMA ophthalmology     Volume:  131     ISSN:  2168-6173     ISO Abbreviation:  JAMA Ophthalmol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-12     Completed Date:  2013-06-05     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  101589539     Medline TA:  JAMA Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  486-94     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
African Americans / ethnology
Aged
Cohort Studies
Female
Follow-Up Studies
Glaucoma / diagnosis*,  ethnology,  psychology*
Gonioscopy
Health Status
Humans
Intraocular Pressure
Male
Middle Aged
Ocular Hypertension / diagnosis,  ethnology,  psychology
Prospective Studies
Quality of Life / psychology*
Questionnaires
Sensitivity and Specificity
Sickness Impact Profile
Tonometry, Ocular
Vision Disorders / diagnosis*
Vision, Binocular*
Vision, Ocular
Visual Field Tests
Visual Fields*
Grant Support
ID/Acronym/Agency:
EY021818/EY/NEI NIH HHS; EY11008/EY/NEI NIH HHS; EY14267/EY/NEI NIH HHS; P30 EY022589/EY/NEI NIH HHS; R01 EY011008/EY/NEI NIH HHS; R01 EY019869/EY/NEI NIH HHS; R01 EY021818/EY/NEI NIH HHS; U10 EY014267/EY/NEI NIH HHS
Comments/Corrections
Comment In:
JAMA Ophthalmol. 2014 Jun;132(6):784-5   [PMID:  24921175 ]
JAMA Ophthalmol. 2014 Jun;132(6):785   [PMID:  24921176 ]

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