Document Detail

Association between prepartum maternal iron deficiency and offspring risk of schizophrenia: population-based cohort study with linkage of Danish national registers.
MedLine Citation:
PMID:  20093425     Owner:  NLM     Status:  MEDLINE    
Recent findings suggest that maternal iron deficiency may increase the risk of schizophrenia-spectrum disorder in offspring. We initiated this study to determine whether maternal prepartum anemia influences offspring risk of schizophrenia. We conducted a population-based study with individual record linkage of the Danish Civil Registration System, the Danish Psychiatric Central Register, and the Danish National Hospital Register. In a cohort of 1,115,752 Danish singleton births from 1978 to 1998, cohort members were considered as having a maternal history of anemia if the mother had received a diagnosis of anemia at any time during the pregnancy. Cohort members were followed from their 10th birthday until onset of schizophrenia, death, or December 31, 2008, whichever came first. Adjusted for relevant confounders, cohort members whose mothers had received a diagnosis of anemia during pregnancy had a 1.60-fold (95% confidence interval = 1.16-2.15) increased risk of schizophrenia. Although the underlying mechanisms are unknown and independent replication is needed, our findings suggest that maternal iron deficiency increases offspring risk of schizophrenia.
Holger J Sørensen; Philip R Nielsen; Carsten B Pedersen; Preben B Mortensen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-21
Journal Detail:
Title:  Schizophrenia bulletin     Volume:  37     ISSN:  1745-1701     ISO Abbreviation:  Schizophr Bull     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-23     Completed Date:  2012-01-17     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0236760     Medline TA:  Schizophr Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  982-7     Citation Subset:  IM    
Department of Psychiatry, Amager, University Hospital of Copenhagen, Digevej 110, DK2300 S, Denmark.
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MeSH Terms
Anemia, Iron-Deficiency / complications*
Cohort Studies
Denmark / epidemiology
Follow-Up Studies
Iron / deficiency*
Pregnancy Complications / blood
Prenatal Exposure Delayed Effects / physiopathology*
Prospective Studies
Risk Factors
Schizophrenia / epidemiology*,  etiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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