| Association between plasma leptin levels and diabetes mellitus. | |
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MedLine Citation:
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PMID: 20946007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Leptin is an important adipose tissue-derived hormone that has been shown to be involved in pathophysiological mechanisms related to cardiovascular disease and diabetes. However, few studies have examined the association between plasma leptin and diabetes mellitus in humans. Also, it is not clear if this association is present among women as well as in men. Therefore, we examined the association between plasma leptin levels and diabetes mellitus in a representative multiethnic sample of U.S. adults. METHODS: We examined the 1988-1994 third National Health and Nutrition Examination Survey (NHANES III) participants >20 years of age (n = 5,599, 54.7% women). Plasma leptin levels were categorized into quartiles (women, <7.68 fg/L, 7.68-13.18 fg/L, 13.19-21.70 fg/L, >21.70 fg/L; men, <2.64 fg/L, 2.64-4.36 fg/L, 4.37-7.12 fg/L, >7.12 fg/L). Diabetes mellitus was defined as fasting glucose ≥126 mg/dL, non-fasting glucose ≥200 mg/dL or use of oral hypoglycemic medication or insulin (n = 395). RESULTS: Higher plasma leptin levels were initially found to be associated with diabetes mellitus after adjusting for age, sex, race/ethnicity, education, smoking, alcohol intake, hypertension, serum cholesterol and C-reactive protein [odds ratio (OR), 3.79; confidence interval (CI), 2.05-7.00; P trend <0.0001). However, when we additionally adjusted for body mass index (BMI), the association between plasma leptin levels and diabetes mellitus disappeared in both men (OR, 1.07; CI, 0.59-1.94; P trend = 0.5004) and women (OR, 0.86; CI, 0.49-1.51; P trend = 0.2819). CONCLUSION: Higher plasma leptin levels are not independently associated with diabetes mellitus after adjustment for BMI. The null association was evident both in women as well as in men. |
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Authors:
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Pavani Bandaru; Anoop Shankar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-14 |
Journal Detail:
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Title: Metabolic syndrome and related disorders Volume: 9 ISSN: 1557-8518 ISO Abbreviation: Metab Syndr Relat Disord Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-21 Completed Date: 2011-05-04 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 101150318 Medline TA: Metab Syndr Relat Disord Country: United States |
Other Details:
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Languages: eng Pagination: 19-23 Citation Subset: IM |
Affiliation:
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Department of Community Medicine, West Virginia University School of Medicine, Morgantown, West Virginia 26506-9190, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Body Mass Index Case-Control Studies Cohort Studies Diabetes Mellitus / blood*, epidemiology, ethnology Female Humans Leptin / blood* Male Middle Aged Overweight / blood, epidemiology, ethnology United States / epidemiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R03 ES018888-01/ES/NIEHS NIH HHS; R03 ES018888-02/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Leptin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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