Document Detail

Association between obstructive sleep apnea and cancer incidence in a large multicenter Spanish cohort.
MedLine Citation:
PMID:  23155146     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Obstructive sleep apnea (OSA) has been associated with increased cancer mortality, but whether it is also associated with cancer incidence is unknown.
OBJECTIVES: To investigate whether OSA is associated with increased cancer incidence in a large clinical cohort.
METHODS: A multicenter, clinical cohort study including consecutive patients investigated for suspected OSA between 2003 and 2007 in seven Spanish teaching hospitals. Apnea-hypopnea index (AHI) and percent nighttime with oxygen saturation less than 90% (TSat(90)) were used as surrogates of OSA severity, both as continuous variables and categorized by tertiles. Cox proportional hazards regression analyses were used to calculate hazard ratio (HR) and 95% confidence interval (CI) for cancer incidence after adjusting for confounding variables.
MEASUREMENTS AND MAIN RESULTS: A total of 4,910 patients were analyzed (median follow-up, 4.5 yr; interquartile range, 3.4-5.2). Compared with the lower TSat(90) category (<1.2%), the adjusted hazards (95% CI) of cancer incidence for increasing categories were 1.58 (1.07-2.34) for TSat(90) 1.2-12% and 2.33 (1.57-3.46) for TSat(90) greater than 12%. Continuous TSat(90) was also associated with cancer incidence (adjusted HR, 1.07 [1.02-1.13] per 10-unit increase in TSat(90)). In stratified analyses, TSat(90) was associated with cancer incidence in patients younger than 65 years (adjusted HR, 1.13 [95% CI, 1.06-1.21] per 10-unit increase in TSat(90)) and males (adjusted HR, 1.11 [95% CI, 1.04-1.17] per 10-unit increase in TSat(90)). AHI was not associated with cancer incidence in the adjusted analyses, except for patients younger than 65 years (adjusted HR for AHI >43 vs. <18.7, 1.66; 95% CI, 1.04-2.64).
CONCLUSIONS: Increased overnight hypoxia as a surrogate of OSA severity was associated with increased cancer incidence. This association seems to be limited to men and patients younger than 65 years of age.
Francisco Campos-Rodriguez; Miguel A Martinez-Garcia; Montserrat Martinez; Joaquin Duran-Cantolla; Monica de la Peña; María J Masdeu; Monica Gonzalez; Felix del Campo; Inmaculada Gallego; Jose M Marin; Ferran Barbe; Jose M Montserrat; Ramon Farre;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2012-11-15
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  187     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-03-17     Revised Date:  2013-09-23    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-105     Citation Subset:  AIM; IM    
Respiratory Department, Hospital Universitario de Valme, Sevilla, Spain.
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MeSH Terms
Age Factors
Middle Aged
Neoplasms / epidemiology*
Retrospective Studies
Sex Factors
Sleep Apnea, Obstructive / epidemiology*
Spain / epidemiology
Comment In:
Am J Respir Crit Care Med. 2013 Aug 1;188(3):399   [PMID:  23905531 ]
Am J Respir Crit Care Med. 2013 Aug 1;188(3):399-400   [PMID:  23905532 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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