Document Detail


Association Between Maternal and Fetal TLR4 (896A>G, 1196C>T) Gene Polymorphisms and the Risk of Pre-term Birth in the Polish Population.
MedLine Citation:
PMID:  23289411     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PROBLEM: Bacteria activates Toll-like receptor 4 on immune system cells leading to preterm birth (PTB). The aim of study was to evaluate the impact of maternal and fetal carriage of TLR4 gene polymorphisms on the risk of PTB. METHOD OF STUDY: Frequency of TLR4 (896A>G, 1196C>T) variants was determined in 121 women who delivered preterm, 152 women who delivered at term, 49 term newborns and 35 preterm newborns with the use of PCR-RFLP. RESULTS: We found no associations between frequency of TLR4 polymorphic alleles in mothers and fetuses and the risk of delivery before 37th week of pregnancy. However significantly lower frequency of TLR4 1196T allele was observed in subgroup of mothers who delivered before 33rd week comparing with those who delivered later (4,4% versus 14,2%, OR = 0,28 (95%CI: 0,04-0,99). CONCLUSIONS: Maternal carriage of TLR4 1196T allele may be associated with reduced risk of PTB before 33rd week of gestation in Polish population.
Authors:
Adam Bitner; Wojciech Sobala; Jarosław Kalinka
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-7
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  -     ISSN:  1600-0897     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 John Wiley & Sons A/S.
Affiliation:
Department of Perinatology, First Chair of Gynecology and Obstetrics, Medical University of Lodz, Poland.
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