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Association Between Mannose-Binding Lectin Gene Polymorphisms And Necrotizing Enterocolitis In Preterm Infants.
MedLine Citation:
PMID:  22331020     Owner:  NLM     Status:  Publisher    
OBJECTIVES:: To evaluate whether polymorphisms of the Mannose-Binding Lectin (MBL-2) gene and MBL serum levels on admission to Neonatal Intensive Care Unit (NICU) are associated with Necrotizing enterocolitis (NEC) in preterm infants and to verify MBL expression in NEC bowels. METHODS:: In this retrospective cohort study, 107 neonates (41 with NEC and 66 controls) were included. MBL-2 genotyping for the promoter polymorphism -221 and for the exon 1 variant alleles at codons 52, 54, and 57 was performed. MBL levels were determined by ELISA in 55 infants. Immunohistochemical staining for MBL expression was performed on bowel specimens. The main study outcome was severe NEC (Bell's stages II/III). RESULTS:: The -221 Y allele and the MBL-2 YY genotype were more frequent in neonates with severe NEC than in controls (p = 0.04 and p = 0.004, respectively). In multivariate analysis, the MBL-2 YA/YA genotype was associated with NEC (OR = 3.03; 95%CI 1.13-8.13, p = 0.024). Neonates with NEC had MBL level on admission >400ng/ml more frequently than controls (p = 0.043). Among neonates with severe NEC, all deceased neonates were carriers of high or intermediate producing MBL-2 genotypes (p = 0.035). Finally, MBL was highly expressed in intestinal tissue from infants with NEC. CONCLUSIONS:: MBL-2 genotypes associated to high MBL serum levels represent a risk factor for NEC. This finding, together with the MBL expression in bowel tissue, supports a role of MBL in the pathogenesis of NEC.
Giusi Prencipe; Chiara Azzari; Maria Moriondo; Rita Devito; Rita Inglese; Marco Pezzullo; Fiammetta Piersigilli; Alessandro Trucchi; Fabrizio De Benedetti; Cinzia Auriti
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-10
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  -     ISSN:  1536-4801     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
*Laboratory of Rheumatology, Bambino Gesù Children's Hospital, Roma, Italy †Department of Pediatrics, Anna Meyer Children's University Hospital, Firenze, Italy ‡Division of Pathology, Bambino Gesù Children's Hospital, Roma, Italy §Clinical Chemistry Laboratory, Bambino Gesù Children's Hospital, Roma, Italy ||Core facilities, Bambino Gesù Children's Hospital, Roma, Italy ¶Department of Medical and Surgical Neonatology, Bambino Gesù Children's Hospital, Roma, Italy.
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