Document Detail

Association Between Low Colonic Short-Chain Fatty Acids and High Bile Acids in High Colon Cancer Risk Populations.
MedLine Citation:
PMID:  22136517     Owner:  NLM     Status:  Publisher    
We propose that the influence of diet on colon cancer risk is mediated by the microbiota. To investigate how dietary fat influences risk, we compared the colonic contents of 12 adult high-risk African Americans (AAs) and 10 Caucasian Americans (CAs) who consumed a high-fat diet (123 ± 11 g/d and 129 ± 17 g/d, respectively) to 13 native Africans (NAs) who subsisted on a low-fat (38 ± 3.0 g/d) diet, all aged 50-60 yr. The colonic bile acids were measured by LC-MS and the short-chain fatty acids (SCFAs) by GC. The chief secondary colonic bile acids, deoxycholic acid and lithocholic acid, were correlated with fat intake and similar between AAs and CAs, but 3-4 times higher than in AAs (p < 0.05). The major SCFAs were lower in AAs (p < 0.001) and CAs (p < 0.001) compared to AAs, but conversely, the branched chain fatty acids (BFCA) were higher. Our results suggest that the higher risk of colon cancer in Americans may be partly explained by their high-fat and high-protein, low complex carbohydrate diet, which produces colonic residues that promote microbes to produce potentially carcinogenic secondary bile acids and less antineoplastic SCFAs. The role of BCFA in colonic carcinogenesis deserves further study.
Junhai Ou; James P Delany; Ming Zhang; Sumit Sharma; Stephen J D O'Keefe
Related Documents :
4020827 - Synthesis and antiinflammatory and analgesic activity of 5-aroyl-1,2-dihydro-3h-pyrrolo...
11537207 - Alkyl phosphonic acids and sulfonic acids in the murchison meteorite.
21699757 - Developmentally dependent and different roles of fatty acids omega-6 and omega-3.
12699387 - Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase g2 (cpg2) show...
18965487 - Determination of sulfide with chloranilic acid by biamperometric and automatic potentio...
41337 - The isoelectric point of thrombin and its behaviour compared to prothrombin at some sol...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-2
Journal Detail:
Title:  Nutrition and cancer     Volume:  -     ISSN:  1532-7914     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a Department of Gastroenterology , Hepatology and Nutrition, School of Medicine, University of Pittsburgh , Pittsburgh , Pennsylvania , USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Diferential Effect of Oral Dehydroepiandrosterone-Sulphate on Metabolic Syndrome Features in Pre- an...
Next Document:  Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones...