Document Detail

The association between food insecurity and inflammation in the US adult population.
MedLine Citation:
PMID:  22698057     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To expand the understanding of potential pathways through which food insecurity is associated with adverse health outcomes, we investigated whether food insecurity is associated with nutritional levels, inflammatory response, and altered immune function.
METHODS: We performed a cross-sectional analysis of the National Health and Nutrition Examination Survey (1999-2006) with 12,191 participants. We assessed food insecurity using the US Department of Agriculture food security scale module and measured clinical biomarkers from blood samples obtained during participants' visits to mobile examination centers.
RESULTS: Of the study population, 21.5% was food insecure. Food insecurity was associated with higher levels of C-reactive protein (adjusted odds ratio [AOR]=1.21; 95% confidence interval [CI]=1.04, 1.40) and of white blood cell count (AOR=1.36; 95% CI=1.11, 1.67). White blood cell count partly mediated the association between food insecurity and C-reactive protein.
CONCLUSIONS: These findings show that food insecurity is associated with increased inflammation, a correlate of chronic diseases. Immune response also appears to be a potential mediator in this pathway.
Charitha Gowda; Craig Hadley; Allison E Aiello
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Publication Detail:
Type:  Journal Article     Date:  2012-06-14
Journal Detail:
Title:  American journal of public health     Volume:  102     ISSN:  1541-0048     ISO Abbreviation:  Am J Public Health     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-12     Completed Date:  2012-10-12     Revised Date:  2014-08-10    
Medline Journal Info:
Nlm Unique ID:  1254074     Medline TA:  Am J Public Health     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1579-86     Citation Subset:  AIM; IM    
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MeSH Terms
Age Factors
C-Reactive Protein / metabolism
Cross-Sectional Studies
Ethnic Groups
Food Supply / statistics & numerical data*
Immune System / physiology*
Inflammation / blood*
Leukocyte Count
Middle Aged
Nutrition Surveys
Nutritional Status
Socioeconomic Factors
United States
Young Adult
Reg. No./Substance:
9007-41-4/C-Reactive Protein
Comment In:
Am J Public Health. 2013 Jan;103(1):e4-5   [PMID:  23153161 ]
Am J Public Health. 2013 Jan;103(1):e4   [PMID:  23153136 ]
Am J Public Health. 2013 Mar;103(3):e5   [PMID:  23327245 ]
Am J Public Health. 2013 Mar;103(3):e6   [PMID:  23327268 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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