Document Detail

Association between exaggerated blood pressure response to exercise and serum asymmetric dimethylarginine levels.
MedLine Citation:
PMID:  20453387     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The exaggerated blood pressure response to exercise (EBPR) is an independent predictor of hypertension. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide inhibitor and higher plasma levels of ADMA are related to increased cardiovascular risk. The aim of this study is to identify the relationship between ADMA and EBPR.
METHODS AND RESULTS: A total of 66 patients (36 with EBPR and 30 as controls) were enrolled in the study. EBPR is defined as blood pressure (BP) measurements > or =200/100 mmHg during the treadmill test. All the subjects underwent 24-h ambulatory BP monitoring. L-arginine and ADMA levels were measured using a high performance lipid chromatography technique. The serum ADMA levels were increased in the EBPR group compared to the healthy controls (4.0+/-1.4 vs 2.6+/-1.1 micromol/L respectively, P=0.001), but L-arginine levels were similar in the 2 groups (P=0.19). The serum ADMA levels were detected as an independent predictor of EBPR (odds ratio 2.28; 95% confidence interval 1.22-4.24; P=0.002).
CONCLUSIONS: Serum ADMA levels might play a role in EBPR to exercise.
Mehmet Kayrak; Ahmet Bacaksiz; Mehmet Akif Vatankulu; Selim S Ayhan; Alparslan Taner; Ali Unlü; Mehmet Yazici; Mehmet S Ulgen
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Publication Detail:
Type:  Journal Article     Date:  2010-04-27
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  74     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-27     Completed Date:  2010-09-07     Revised Date:  2011-02-18    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1135-41     Citation Subset:  IM    
Department of Cardiology, Selcuk University Meram School of Medicine Hospital, Meram, Konya, Turkey.
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MeSH Terms
Arginine / analogs & derivatives*,  blood
Blood Pressure / physiology*
Blood Pressure Monitoring, Ambulatory
Cardiovascular Diseases
Case-Control Studies
Chromatography, High Pressure Liquid
Exercise / physiology*
Exercise Test
Hypertension / diagnosis*
Middle Aged
Predictive Value of Tests*
Reg. No./Substance:
30315-93-6/N,N-dimethylarginine; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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