| Association between exaggerated blood pressure response to exercise and serum asymmetric dimethylarginine levels. | |
| | |
MedLine Citation:
|
PMID: 20453387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The exaggerated blood pressure response to exercise (EBPR) is an independent predictor of hypertension. Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide inhibitor and higher plasma levels of ADMA are related to increased cardiovascular risk. The aim of this study is to identify the relationship between ADMA and EBPR. METHODS AND RESULTS: A total of 66 patients (36 with EBPR and 30 as controls) were enrolled in the study. EBPR is defined as blood pressure (BP) measurements > or =200/100 mmHg during the treadmill test. All the subjects underwent 24-h ambulatory BP monitoring. L-arginine and ADMA levels were measured using a high performance lipid chromatography technique. The serum ADMA levels were increased in the EBPR group compared to the healthy controls (4.0+/-1.4 vs 2.6+/-1.1 micromol/L respectively, P=0.001), but L-arginine levels were similar in the 2 groups (P=0.19). The serum ADMA levels were detected as an independent predictor of EBPR (odds ratio 2.28; 95% confidence interval 1.22-4.24; P=0.002). CONCLUSIONS: Serum ADMA levels might play a role in EBPR to exercise. |
| | |
Authors:
|
Mehmet Kayrak; Ahmet Bacaksiz; Mehmet Akif Vatankulu; Selim S Ayhan; Alparslan Taner; Ali Unlü; Mehmet Yazici; Mehmet S Ulgen |
Related Documents
:
|
19501757 - Salt taste sensitivity threshold and exercise-induced hypertension. 18799957 - Validation of the microlife watch bp office professional device for office blood pressu... 6637817 - Effects of diltiazem on cardiovascular responses during exercise in systemic hypertensi... 16172777 - Accidental provocation of phaeochromocytoma: the forgotten hazard of metoclopramide? 1483747 - Enzyme mechanisms for pyruvate-to-lactate flux attenuation: a study of sherpas, quechua... 19542687 - Sociodemographic variation in the perception of barriers to exercise among japanese adu... |
Publication Detail:
|
Type: Journal Article Date: 2010-04-27 |
Journal Detail:
|
Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 74 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-27 Completed Date: 2010-09-07 Revised Date: 2011-02-18 |
Medline Journal Info:
|
Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
|
Languages: eng Pagination: 1135-41 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Selcuk University Meram School of Medicine Hospital, Meram, Konya, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Arginine / analogs & derivatives*, blood Blood Pressure / physiology* Blood Pressure Monitoring, Ambulatory Cardiovascular Diseases Case-Control Studies Chromatography, High Pressure Liquid Exercise / physiology* Exercise Test Female Humans Hypertension / diagnosis* Male Middle Aged Predictive Value of Tests* |
| Chemical | |
Reg. No./Substance:
|
30315-93-6/N,N-dimethylarginine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relation between plaque components and plaque prolapse after drug-eluting stent implantation--virtua...
Next Document: Left ventricular outflow tract obstruction in complete transposition of the great arteries--echocard...