Document Detail


The Association Between Development and Progression of Multinodular Goiter and Thyroid-Stimulating Hormone Receptor Gene D727E and P52T Polymorphisms.
MedLine Citation:
PMID:  23336574     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aim: This study has been performed on a Turkish population with multinodular goiter (MNG) to investigate the thyroid-stimulating hormone receptor (TSHR) gene D727E and P52T polymorphisms. Methods: DNA samples were isolated from 300 patients with MNG and 142 controls. Polymerase chain reaction-restriction fragment length polymorphism and agarose gel electrophoresis were used. Results: The D727E polymorphism G-allele frequency and the CG and GG genotypes were significantly higher in patients with MNG. However, there was no significant difference in the P52T polymorphism between patients and control subjects. Conclusions: As a conclusion, the D727E polymorphism G allele may be related to MNG development in the studied population.
Authors:
Banu Bayram; Resit Sonmez; Sedat Bozari; Harun Onlu; Züleyha Turkoglu; Fezan Sahin Mutlu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Genetic testing and molecular biomarkers     Volume:  17     ISSN:  1945-0257     ISO Abbreviation:  Genet Test Mol Biomarkers     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101494210     Medline TA:  Genet Test Mol Biomarkers     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-14     Citation Subset:  IM    
Affiliation:
1 Department of Biology, Faculty of Arts and Science, Mus Alparslan University , Mus, Turkey .
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