Document Detail


The association between clinical and radiographic periodontitis measurements during periodontal maintenance.
MedLine Citation:
PMID:  23205917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The purpose of the present study is to examine the association between clinical and radiographic periodontitis measurements during 2 years of periodontal maintenance.
METHODS: Secondary analyses were performed from a 2-year, double-masked, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of subantimicrobial dose doxycycline (SDD) in 128 postmenopausal osteopenic females with moderate-to-severe chronic periodontitis. Relative clinical attachment level (relative CAL) and probing depth (PD) measurements were made. Posterior vertical bitewings were taken for alveolar bone density (ABD) and alveolar bone height (ABH) measurements. Generalized estimating equations were used to model associations.
RESULTS: One-year ABD changes and 1-year relative CAL/PD changes did not predict 2-year ABH changes and ABH/ABD changes, respectively. Baseline relative CAL and PD were positively associated with baseline ABH loss (P <0.0001), and baseline PDs were associated with subsequent ABD and ABH loss (P <0.05 for each). Among placebo (but not SDD) participants, relative CAL changes were associated with concurrent ABD loss (P = 0.027) when considering 1- and 2-year changes combined. The odds of ABH loss were higher among sites with concurrent 1-year ABD loss versus no change (odds ratio [OR] = 3.15, P <0.0001) or concurrent PD increases versus no change (OR = 1.88, P = 0.0025) when considering 1- and 2-year changes combined.
CONCLUSIONS: In postmenopausal osteopenic females undergoing periodontal maintenance, baseline PD was associated with subsequent ABD and ABH loss. Although no longitudinal change preceded another measurement change, changes in PDs and relative CALs appeared to reflect changes in the underlying alveolar bone over time.
Authors:
Jeffrey B Payne; Pirkka V Nummikoski; David M Thompson; Lorne M Golub; Julie A Stoner
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-12-03
Journal Detail:
Title:  Journal of periodontology     Volume:  84     ISSN:  1943-3670     ISO Abbreviation:  J. Periodontol.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-30     Completed Date:  2014-08-29     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1382-90     Citation Subset:  D; IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00066027
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MeSH Terms
Descriptor/Qualifier:
Aged
Alveolar Bone Loss / prevention & control,  radiography
Alveolar Process / radiography
Anti-Bacterial Agents / administration & dosage*
Bone Density / physiology
Bone Diseases, Metabolic / complications
Chronic Periodontitis / classification,  prevention & control*,  radiography
Double-Blind Method
Doxycycline / administration & dosage*
Female
Follow-Up Studies
Humans
Middle Aged
Periodontal Attachment Loss / classification,  prevention & control
Periodontal Index
Periodontal Pocket / classification,  prevention & control
Placebos
Postmenopause / physiology
Radiography, Bitewing
Safety
Treatment Outcome
Grant Support
ID/Acronym/Agency:
R01 DE012872/DE/NIDCR NIH HHS; R01DE012872/DE/NIDCR NIH HHS; R03 DE019805/DE/NIDCR NIH HHS; R03DE019805/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Placebos; N12000U13O/Doxycycline
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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