Document Detail


Association between changes in air pollution levels during the Beijing Olympics and biomarkers of inflammation and thrombosis in healthy young adults.
MedLine Citation:
PMID:  22665106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Air pollution is a risk factor for cardiovascular diseases (CVD), but the underlying biological mechanisms are not well understood.
OBJECTIVE: To determine whether markers related to CVD pathophysiological pathways (biomarkers for systemic inflammation and thrombosis, heart rate, and blood pressure) are sensitive to changes in air pollution.
DESIGN, SETTING, AND PARTICIPANTS: Using a quasi-experimental opportunity offered by greatly restricted air pollution emissions during the Beijing Olympics, we measured pollutants daily and the outcomes listed below in 125 healthy young adults before, during, and after the 2008 Olympics (June 2-October 30). We used linear mixed-effects models to estimate the improvement in outcome levels during the Olympics and the anticipated reversal of outcome levels after pollution controls ended to determine whether changes in outcome levels were associated with changes in pollutant concentrations.
MAIN OUTCOME MEASURES: C-reactive protein (CRP), fibrinogen, von Willebrand factor, soluble CD40 ligand (sCD40L), soluble P-selectin (sCD62P) concentrations; white blood cell count (WBC); heart rate; and blood pressure.
RESULTS: Concentrations of particulate and gaseous pollutants decreased substantially (-13% to -60%) from the pre-Olympic period to the during-Olympic period. Using 2-sided tests conducted at the .003 level, we observed statistically significant improvements in sCD62P levels by -34.0% (95% CI, -38.4% to -29.2%; P < .001) from a pre-Olympic mean of 6.29 ng/mL to a during-Olympic mean of 4.16 ng/mL and von Willebrand factor by -13.1% (95% CI, -18.6% to -7.5%; P < .001) from 106.4% to 92.6%. After adjustments for multiple comparisons, changes in the other outcomes were not statistically significant. In the post-Olympic period when pollutant concentrations increased, most outcomes approximated pre-Olympic levels, but only sCD62P and systolic blood pressure were significantly worsened from the during-Olympic period. The fraction of above-detection-limit values for CRP (percentage ≥ 0.3 mg/L) was reduced from 55% in the pre-Olympic period to 46% in the during-Olympic period and reduced further to 36% in the post-Olympic period. Interquartile range increases in pollutant concentrations were consistently associated with statistically significant increases in fibrinogen, von Willebrand factor, heart rate, sCD62P, and sCD40L concentrations.
CONCLUSIONS: Changes in air pollution levels during the Beijing Olympics were associated with acute changes in biomarkers of inflammation and thrombosis and measures of cardiovascular physiology in healthy young persons. These findings are of uncertain clinical significance.
Authors:
David Q Rich; Howard M Kipen; Wei Huang; Guangfa Wang; Yuedan Wang; Ping Zhu; Pamela Ohman-Strickland; Min Hu; Claire Philipp; Scott R Diehl; Shou-En Lu; Jian Tong; Jicheng Gong; Duncan Thomas; Tong Zhu; Junfeng Jim Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JAMA     Volume:  307     ISSN:  1538-3598     ISO Abbreviation:  JAMA     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-05     Completed Date:  2012-06-08     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2068-78     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Air Pollution / adverse effects*,  analysis,  prevention & control*
Anniversaries and Special Events
Biological Markers / blood*
Blood Pressure
China / epidemiology
Environmental Exposure / adverse effects*
Environmental Monitoring
Epidemiological Monitoring
Female
Health Status
Heart Rate
Humans
Inflammation / blood,  epidemiology*
Male
Sports
Thrombosis / blood,  epidemiology*
Young Adult
Grant Support
ID/Acronym/Agency:
1R01ES015864/ES/NIEHS NIH HHS; 5P30ES007048/ES/NIEHS NIH HHS; P30 ES005022/ES/NIEHS NIH HHS; P30ES005022/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections
Comment In:
Nat Rev Cardiol. 2012 Jul;9(7):375   [PMID:  22665322 ]
JAMA. 2012 May 16;307(19):2100-2   [PMID:  22665112 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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