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Association Between Bronchopulmonary Dysplasia and MBL2 and IL1-RN Polymorphisms.
MedLine Citation:
PMID:  22882323     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The imbalance between pro-inflammatory and anti-inflammatory cytokines may possibly play a role in the development of bronchopulmonary dysplasia (BPD) in preterm infants. Mannose binding lectin (MBL) codon 54 and interleukin 1 receptor antagonist gene (IL1-RN) polymorphisms cause genetic predisposition to increased risk of infection and inflammation, therefore may increase the risk of BPD. The aim of the study was to investigate the relationship between MBL, IL1-RN gene polymorphisms and BPD development in preterm infants. METHODS: MBL codon 54 and IL1-RN polymorphisms were studied in 71 infants who were born at less than 32 weeks of gestation, with the diagnosis of BPD (Group 1) and control group of preterm infants without BPD (Group 2). RESULTS: IL1-RN and MBL2 variant genes were closely associated with the increased risk of BPD (both of them p<0.001) together with significantly lower birth weights (p<0.001 and p=0.001, respectively), lower 5-minute Apgar scores (p=0.009 for both genes) and increased neonatal infection rates (p<0.001 and p<0.009, respectively).IL1 RN 1/1 genotype was protective (OR, 0.075; 95% CI, 0.019-0.76) while IL1-RN 2/2 genotype increased the risk for BPD (OR, 11.7; 95% CI, 1.3-103.6). MBL-AA genotype was protective against BPD (OR, 0.066; 95% CI, 0.02-0.2) whereas MBL-BB genotype increased the susceptibility for the development of BPD (OR, 23.8; 95% CI, 2.8-200.6). CONCLUSIONS: MBL and IL 1 RN polymorphisms were found closely related with low birth weights, increased the risk of neonatal sepsis and BPD development in preterm infants.
Authors:
Bilin Cetinkaya Cakmak; Sebnem Calkavur; Ferda Ozkinay; Ozge Altun Koroglu; Huseyin Onay; Gulcin Itirli; Emin Karaca; Mehmet Yalaz; Mete Akisu; Nilgün Kultursay
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-13
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
Affiliation:
Ege University Faculty of Medicine, Department of Pediatrics, Division of Neonatology.
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