Document Detail

Association Between Atopic Dermatitis and Obesity in Adulthood.
MedLine Citation:
PMID:  21999468     Owner:  NLM     Status:  Publisher    
Background:  Obesity in early childhood is associated with increased risk for and severity of atopic dermatitis (AD). Objective:  To determine whether obesity in adulthood is associated with risk of AD. Methods:  A retrospective case-control study of 2,090 adults with questionnaire, height weight, and skin-prick testing between January 1994 and December 2003. Results:  (1) Obesity in adults is associated with increased AD (multinomial logistic regression; aOR=1.42, 95% CI=1.07-1.87, P=0.01), but not non-atopic dermatitis (aOR=0.44, 95% CI=0.13-1.44, P=0.17). (2) Obesity was also associated with increased atopic asthma (aOR=1.98, 95% CI=1.47-2.66, P<0.0001), but not associated with non-atopic asthma (P=0.20), atopic or non-atopic rhinoconjunctivitis (P=0.08 and 0.31) or food allergies (P=0.67 and 0.35), or atopy (P=0.40). The association between obesity and atopic dermatitis remained significant even when controlling for history of asthma, rhinoconjunctivitis and food allergies (aOR=1.40, 95% CI=1.05-1.86, P=0.02) or in subset analyses of subjects with AD alone (aOR=1.96, 95% CI=1.02-3.75, P=0.04) and with comorbid asthma, rhinoconjunctivitis and/or food allergies (aOR=1.40, 95% CI=1.03-1.91, P=0.03). Conclusion:  Obesity in adulthood is associated with AD. Further studies are warranted to determine if weight loss may prevent or mitigate AD in adults.
J I Silverberg; N B Silverberg; M Lee-Wong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-16
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 British Association of Dermatologists.
Department of Dermatology, St. Luke's-Roosevelt Hospital and Beth Israel Medical Centers, New York, NY, 10025, USA Department of Allergy and Immunology, Beth Israel Medical Center, New York, NY, 10003, USA.
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