| Association Between ApoE Phenotypes and Telomere Erosion in Alzheimer's Disease. | |
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MedLine Citation:
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PMID: 22016362 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Although several reports suggest that Alzheimer's disease (AD) is associated with shortened telomere length, the clinical relevance of this has not yet been fully elucidated. This study was conducted to clarify the correlation of telomere length with clinical characteristics and ApoE phenotypes in 74 AD patients. Telomere length was determined from genomic DNA extracted from whole blood by quantitative real-time polymerase chain reaction. We found no significant difference in telomere length between the AD and non-dementia elderly control (n = 35) groups. Furthermore, no significant correlation was found among telomere length and the severity of cognitive decline and disease duration, age, or gender difference. However, telomere length was significantly shorter in AD patients with the ApoE4 homozygote than in those with the ApoE4 heterozygote (p < .001) and noncarriers (p < .001). These findings suggest that shortened telomere length may be associated with the ApoE4 homozygote in AD patients. |
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Authors:
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Yusuke Takata; Masayuki Kikukawa; Haruo Hanyu; Shunichi Koyama; Soichiro Shimizu; Takahiko Umahara; Hirofumi Sakurai; Toshihiko Iwamoto; Kazuma Ohyashiki; Junko H Ohyashiki |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-19 |
Journal Detail:
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Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: - ISSN: 1758-535X ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. ny-55178@tokyo-med.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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