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Association between acute corneal hydrops in patients with keratoconus and mitral valve prolapse.
MedLine Citation:
PMID:  21045676     Owner:  NLM     Status:  In-Process    
PURPOSE: To investigate the association between corneal hydrops in patients with keratoconus (KCN) and mitral valve prolapse (MVP).
METHODS: This case-control study included patients with KCN with corneal hydrops who were referred to Labbafinejad Medical Center or a private clinic between March 2006 and March 2008, as the case group. The control group included group-matched individuals who were selected from patients of the same medical centers without any ophthalmic diseases. The size of the control group was 4 times that of the case group to increase the power of the study. All subjects were referred for cardiac examination and underwent 2-dimensional, M-mode, and color Doppler echocardiography. The criteria of Perloff et al were used for diagnosis of MVP. Fisher exact test and logistic regression analysis were used to compare these 2 groups.
RESULTS: Overall, 160 participants (32 cases and 128 controls) with mean age of 31.0 ± 13.2 years were studied. Prevalence of MVP was 65.6% in the case group and 9% in controls (P < 0.001). Patients with hydrops had an odds ratio of 26.7 for having MVP (95% confidence interval, 9.5-75.2). Age- and sex-adjusted analyses revealed that the odds ratio of MVP in the case group was higher than that in the control group.
CONCLUSIONS: There seems to be a correlation between corneal hydrops secondary to KCN and MVP, suggesting further evaluation to assess mitral valve status.
Zahra Rabbanikhah; Mohammad Ali Javadi; Pooya Rostami; Abdolhamid Aghdaie; Mehdi Yaseri; Fatemeh Yahyapour; Marzieh Katibeh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cornea     Volume:  30     ISSN:  1536-4798     ISO Abbreviation:  Cornea     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  154-7     Citation Subset:  IM    
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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