Document Detail

Association of Bartonella species and Coxiella burnetii infection with coronary artery disease.
MedLine Citation:
PMID:  11181164     Owner:  NLM     Status:  MEDLINE    
Coronary artery disease is an inflammatory condition associated with several infections. We prospectively evaluated 155 consecutive patients undergoing coronary angiography for evidence of Bartonella species and Coxiella burnetii infection. All Bartonella cultures were found to be negative. Multivariable logistic regression analysis that controlled for potential confounding factors revealed no association between coronary artery disease and seropositivity to Bartonella henselae (odds ratio [OR], 0.852; 95% confidence interval [CI], 0.293-2.476), Bartonella quintana (OR, 0.425; 95% CI, 0.127-1.479), C. burnetii phase 1 (OR, undefined), and C. burnetii phase 2 (OR, 0.731; 95% CI, 0.199-2.680). The geometric mean titer (GMT) for C. burnetii phase 1 assay was slightly higher in persons with coronary artery disease than in those without such disease (P<.02). B. henselae, B. quintana, and C. burnetii seropositivity was not strongly associated with coronary artery disease. On the basis of GMTs, C. burnetii infection may have a modest association with coronary artery disease.
P T Ender; J Phares; G Gerson; S E Taylor; R Regnery; R C Challener; M J Dolan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2001-01-24
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  183     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  831-4     Citation Subset:  AIM; IM    
Division of Infectious Diseases, Wright-Patterson Air Force Base, Dayton, Ohio, 45433-5529, USA.
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MeSH Terms
Bartonella / isolation & purification*
Bartonella Infections / complications*,  epidemiology
Case-Control Studies
Coronary Angiography
Coronary Disease / etiology*,  microbiology
Coxiella burnetii / isolation & purification*
Cross-Sectional Studies
Logistic Models
Odds Ratio
Ohio / epidemiology
Prospective Studies
Q Fever / complications*,  epidemiology
Risk Factors
Seroepidemiologic Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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