Document Detail

The association of aspirin use with age-related macular degeneration.
MedLine Citation:
PMID:  23337937     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether regular aspirin use is associated with a higher risk for developing age-related macular degeneration (AMD) by using analyzed data from a 15-year prospective cohort.
METHODS: A prospective analysis was conducted of data from an Australian population-based cohort with 4 examinations during a 15-year period (1992-1994 to 2007-2009). Participants completed a detailed questionnaire at baseline assessing aspirin use, cardiovascular disease status, and AMD risk factors. Age-related macular degeneration was graded side-by-side from retinal photographs taken at each study visit to assess the incidence of neovascular (wet) AMD and geographic atrophy (dry AMD) according to the international AMD classification.
RESULTS: Of 2389 baseline participants with follow-up data available, 257 individuals (10.8%) were regular aspirin users and 63 of the 2389 developed neovascular AMD. Persons who were regular aspirin users were more likely to have incident neovascular AMD: the 15-year cumulative incidence was 9.3% in users and 3.7% in nonusers. After adjustment for age, sex, smoking, history of cardiovascular disease, systolic blood pressure, and body mass index, persons who were regular aspirin users had a higher risk of developing neovascular AMD (odds ratio [OR], 2.46; 95% CI, 1.25-4.83). The association showed a dose-response effect (multivariate-adjusted P = .01 for trend). Aspirin use was not associated with the incidence of geographic atrophy (multivariate-adjusted OR, 0.99; 95% CI, 0.59-1.65).
CONCLUSION: Regular aspirin use is associated with increased risk of incident neovascular AMD, independent of a history of cardiovascular disease and smoking.
Gerald Liew; Paul Mitchell; Tien Yin Wong; Elena Rochtchina; Jie Jin Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JAMA internal medicine     Volume:  173     ISSN:  2168-6114     ISO Abbreviation:  JAMA Intern Med     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-04-16     Revised Date:  2014-03-05    
Medline Journal Info:
Nlm Unique ID:  101589534     Medline TA:  JAMA Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  258-64     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Aspirin / administration & dosage,  adverse effects*
Cardiovascular Diseases / drug therapy,  prevention & control
Cohort Studies
Logistic Models
Macular Degeneration / classification,  epidemiology,  etiology*
Middle Aged
Prospective Studies
Risk Factors
Reg. No./Substance:
Comment In:
Evid Based Med. 2014 Feb;19(1):e6   [PMID:  23771726 ]
Praxis (Bern 1994). 2013 Jun 5;102(12):753-4   [PMID:  23735769 ]
JAMA Intern Med. 2013 Aug 12;173(15):1476-7   [PMID:  23939526 ]
JAMA Intern Med. 2013 Aug 12;173(15):1476   [PMID:  23939525 ]
JAMA Intern Med. 2013 Feb 25;173(4):266   [PMID:  23338524 ]
JAMA Intern Med. 2013 Feb 25;173(4):264-6   [PMID:  23338290 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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