Document Detail

Association of antithrombin activity with plasma aldosterone concentration and plasma renin activity in pregnant women.
MedLine Citation:
PMID:  23273069     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test the hypothesis that the blood antithrombin (AT) activity is correlated with the plasma aldosterone concentration (PAC), the plasma renin activity (PRA), and/or the PAC-to-PRA ratio during the late stage of pregnancy.
METHODS: The AT activity, PAC, and PRA were determined within 7 days prior to delivery in 47 women, consisting of 30 normotensive and 6 hypertensive women with singleton pregnancies and 11 normotensive women with twin pregnancies.
RESULTS: The median values of the 47 women were 86% of the normal activity level for the AT activity, 442 pg/mL for the PAC, 3.7 ng/mL/h for the PRA, and 108 pg/mL per ng/mL/h for the PAC-to-PRA ratio. Women with an AT activity ≤86% had a significantly lower PRA and a higher PAC-to-PRA ratio than women with an AT activity >86% (3.5 ± 3.0 vs. 6.6 ± 4.7 ng/mL/h for PRA, p = 0.008; 156 ± 109 vs. 97 ± 46 pg/mL per ng/h for PAC-to-PRA ratio, p = 0.021). The AT activity was significantly correlated positively with the PRA and negatively with the PAC-to-PRA ratio.
CONCLUSIONS: The existence of a common pathophysiological background between a reduced AT activity and a reduced PRA during the late stage of pregnancy was suggested.
Takashi Yamada; Takahiro Koyama; Itsuko Furuta; Mamoru Morikawa; Takahiro Yamada; Hisanori Minakami
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Publication Detail:
Type:  Journal Article     Date:  2012-12-28
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  32     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2013  
Date Detail:
Created Date:  2013-02-11     Completed Date:  2014-04-22     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  96-103     Citation Subset:  IM    
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MeSH Terms
Aldosterone / blood*
Antithrombins / blood*
Hypertension, Pregnancy-Induced / blood
Plasma Volume
Pregnancy / blood*
Pregnancy, Twin / blood
Prospective Studies
Renin / blood*
Renin-Angiotensin System*
Reg. No./Substance:
0/Antithrombins; 4964P6T9RB/Aldosterone; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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