Document Detail


The association among lipoprotein-associated phospholipase A2 levels, total antioxidant capacity and arousal in male patients with OSA.
MedLine Citation:
PMID:  21698055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The mechanisms of the increased cardiac and vascular events in patients with OSA are not well understood. Arousal which is an important component of OSA was associated with increased sympathetic activation and electrocardiographic changes which prone to arrhythmias. We planned to examine the association among arousal, circulating Lp-PLA2 and total antioxidant capacity in male patients with OSA.
METHODS: Fifty male patients with newly diagnosed OSA were enrolled the study. A full-night polysomnography was performed and arousal index was obtained. Lp-PLA2 concentrations were measured in serum samples with the PLAC Test. Total antioxidant capacity in patients was determined with Antioxidant Assay Kit.
RESULTS: Arousal was positively correlated with LP-PLA2 levels (r=0.43, p=0.002) and was negatively correlated with total antioxidant capacity (r= -0.29, p=0.04). Elevated LP-PLA2 levels and decreased total antioxidant activities were found in the highest arousal quartile compared with the lowest and 2nd quartiles (p=0.02, p=0.05, respectively). LP-PLA2 was an independently predictor of arousal index in regression model (β=0.357, p=0.002)
CONCLUSIONS: This study demonstrated a moderate linear relationship between arousal and LP-PLA2 levels. Also, total antioxidant capacities were decreased in the higher arousal index. Based on the study result, the patients with higher arousal index may be prone to vascular events.
Authors:
Taha T Bekci; Mehmet Kayrak; Aysel Kiyici; Emin Maden; Hatem Ari; Zeynettin Kaya; Turgut Teke; Hakan Akilli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-06-10
Journal Detail:
Title:  International journal of medical sciences     Volume:  8     ISSN:  1449-1907     ISO Abbreviation:  Int J Med Sci     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-23     Completed Date:  2011-10-25     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101213954     Medline TA:  Int J Med Sci     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  369-76     Citation Subset:  IM    
Affiliation:
Department of Pulmonary Medicine, Konya Education and Research Hospital, Konya/ Turkey. tahabekci@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Antioxidants / metabolism*
Arousal*
Biological Markers / blood
Cardiovascular Diseases / blood
Humans
Male
Middle Aged
Phospholipases A2 / blood*
Risk Factors
Sleep Apnea, Obstructive / blood*,  enzymology
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; EC 3.1.1.4/Phospholipases A2
Comments/Corrections

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