Document Detail


Association of Alzheimer's Disease With APOE and IL-1α Gene Polymorphisms.
MedLine Citation:
PMID:  23038715     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Apolipoprotein E (ApoE) gene polymorphisms are thought to be the most important genetic risk factor in the pathogenesis of late onset and sporadic Alzheimer's disease (AD). Moreover, interleukin-1α (IL-1α) is found to be associated with the pathogenesis of AD. In this research, ε2, ε3, and ε4 polymorphisms of ApoE gene and C889T polymorphism of IL-1α gene were genotyped in patients with AD and controls. Genotyping was performed by real-time polymerase chain reaction. ε3/ε3 and ε3/ε4 genotype frequencies were significantly higher in control and case groups, respectively. While ε3 allele frequencies were significantly higher in the control group, ε2 and ε4 allele frequencies were significantly higher among the cases with AD. No difference was found between the groups according to C889T polymorphism of IL-1α. In conclusion, we demonstrated that there was a strong association between ApoE ε4 allele and AD, while there was no relation with IL-1α C889T polymorphisms for this study.
Authors:
Saliha Handan Yildiz; Mujgan Ozdemir Erdogan; Sevilhan Artan; Mustafa Solak; Mehmet Yaman; Belgin Demet Ozbabalik; Evrim Suna Arikan Terzi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  American journal of Alzheimer's disease and other dementias     Volume:  -     ISSN:  1938-2731     ISO Abbreviation:  Am J Alzheimers Dis Other Demen     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101082834     Medline TA:  Am J Alzheimers Dis Other Demen     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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