| The association of adult Onchocerca volvulus with lymphatic vessels. | |
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MedLine Citation:
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PMID: 19803543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunocytochemical examination of onchocercal nodule tissues containing adult Onchocerca volvulus using immuno-markers for blood and lymphatic vessels (vWF, D2-40, podoplanin, Prox-1, and Lyve1) shows a distinct pattern of distribution of these vessels within nodules. Blood vessels were commonly seen associated with organized lymphoid cellular aggregates in the both the outer and inner areas of the nodules. In contrast, the majority of the lymphatic vessel positivity was seen in the central zone in close apposition to the adult parasites, and the remainder usually associated with microfilariae in the outer areas of the nodule. These findings suggest an intimate relationship between adult O. volvulus and lymphatic vessels, including the likely proliferation of lymphatic endothelial cells (lymphangectasia) akin to that seen with other filariae. These findings indicate that adult O. volvulus may migrate via the lymphatic system, and that clinical manifestations of this disease that involve tissue edema may be the result of the location of these worms in the lymphatic system. |
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Authors:
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C D Mackenzie; M K Huntington; S Wanji; R V Lovato; R R Eversole; T G Geary |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of parasitology Volume: 96 ISSN: 1937-2345 ISO Abbreviation: J. Parasitol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-06-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803124 Medline TA: J Parasitol Country: United States |
Other Details:
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Languages: eng Pagination: 219-21 Citation Subset: IM |
Affiliation:
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Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan 48824, USA. mackenz8@msu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Helminth / immunology Antibodies, Monoclonal / immunology Female Humans Lymphatic Vessels / parasitology* Male Microfilaria / immunology, physiology Microscopy, Interference Onchocerca volvulus / immunology, physiology* Onchocerciasis / parasitology*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Helminth; 0/Antibodies, Monoclonal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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