Document Detail

Association of the ACTN3 genotype and physical functioning with age in older adults.
MedLine Citation:
PMID:  19038838     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to examine the association of the alpha-actinin-3 (ACTN3) R577X polymorphism on muscle function and physical performance in older adults.
METHODS: We measured knee extensor torque, midthigh muscle cross-sectional area, muscle quality, short physical performance battery score, and 400-meter walk time at baseline and after 5 years in white older adults aged 70-79 years in the Health, Aging and Body Composition Study cohort (n = 1367). Incident persistent lower extremity limitation (PLL) over 5 years was additionally assessed. We also examined white men in the Osteoporotic Fractures in Men Study, a longitudinal, observational cohort (n = 1152) of men 65 years old or older as a validation cohort for certain phenotypes.
RESULTS: There were no significant differences between genotype groups in men or women for adjusted baseline phenotypes. Male X-homozygotes had a significantly greater adjusted 5-year increase in their 400-meter walk time compared to R-homozygotes and heterozygotes (p =.03). In women, X-homozygotes had a approximately 35% greater risk of incident PLL compared to R-homozygotes (hazard ratio = 0.65, 95% confidence interval = 0.44-0.94). There were no other significant associations between any of the phenotypes and ACTN3 genotype with aging in either cohort.
CONCLUSIONS: The ACTN3 polymorphism may influence declines in certain measures of physical performance with aging in older white adults, based on longitudinal assessments. However, the influence of the ACTN3 R577X polymorphism does not appear to have a strong effect on skeletal muscle-related phenotypes based on the strength and consistency of the associations and lack of replication with regard to specific phenotypes.
Matthew J Delmonico; Joseph M Zmuda; Brent C Taylor; Jane A Cauley; Tamara B Harris; Todd M Manini; Ann Schwartz; Rongling Li; Stephen M Roth; Ben F Hurley; Douglas C Bauer; Robert E Ferrell; Anne B Newman;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  63     ISSN:  1079-5006     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-28     Completed Date:  2008-12-30     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1227-34     Citation Subset:  AIM; IM    
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MeSH Terms
Actinin / genetics*
Motor Activity / physiology*
Muscle, Skeletal / physiology*
Polymorphism, Genetic
Grant Support
1-AG-6-2101/AG/NIA NIH HHS; 1-AG-6-2103/AG/NIA NIH HHS; 1-AG-6-2106/AG/NIA NIH HHS; AG-022791/AG/NIA NIH HHS; K01 AG022791/AG/NIA NIH HHS; K01 AG022791-01/AG/NIA NIH HHS; K01 AG022791-05/AG/NIA NIH HHS; N01 AG062101/AG/NIA NIH HHS; N01 AG062103/AG/NIA NIH HHS; N01 AG062106/AG/NIA NIH HHS; R01 AG021024-05/AG/NIA NIH HHS; R01 AR051124/AR/NIAMS NIH HHS; R01 AR051124-04/AR/NIAMS NIH HHS; R01-AG021024/AG/NIA NIH HHS; R01-AR051124/AR/NIAMS NIH HHS; T32 AG000181/AG/NIA NIH HHS; T32 AG000181-19/AG/NIA NIH HHS; U01 AG027810/AG/NIA NIH HHS; U01 AG027810-01A1/AG/NIA NIH HHS; U01 AG027810-02/AG/NIA NIH HHS; U01 AG027810-03/AG/NIA NIH HHS; U01 AG18197/AG/NIA NIH HHS; U01 AR045647/AR/NIAMS NIH HHS; U01 AR045647-01/AR/NIAMS NIH HHS; U01 AR045647-02/AR/NIAMS NIH HHS; U01 AR045647-03/AR/NIAMS NIH HHS; U01 AR045647-04/AR/NIAMS NIH HHS; U01 AR045647-04S1/AR/NIAMS NIH HHS; U01 AR045647-05/AR/NIAMS NIH HHS; U01 AR045647-06/AR/NIAMS NIH HHS; U01 AR045647-07/AR/NIAMS NIH HHS; U01 AR45580/AR/NIAMS NIH HHS; U01 AR45583/AR/NIAMS NIH HHS; U01 AR45614/AR/NIAMS NIH HHS; U01 AR45632/AR/NIAMS NIH HHS; U01 AR45647/AR/NIAMS NIH HHS; U01 AR45654/AR/NIAMS NIH HHS; U01-AG027810/AG/NIA NIH HHS; UL1 RR024140/RR/NCRR NIH HHS
Reg. No./Substance:
0/ACTN3 protein, human; 11003-00-2/Actinin

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