Document Detail

Association of ACE gene I/D polymorphism with vitiligo: a meta-analysis.
MedLine Citation:
PMID:  23325447     Owner:  NLM     Status:  Publisher    
Associations of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) functional single-nucleotide polymorphisms (SNPs) with vitiligo have been reported, but the results were inconsistent. To investigate the association of SNPs in the intron 16 of ACE gene with vitiligo susceptibility by the meta-analysis, case-control studies were conducted by searching from PubMed, HighWire and China National Knowledge Infrastructure as of May 2011. A total of 6 studies with 828 patients and 1,215 controls was finally identified. All control samples were in Hardy-Weinberg equilibrium. According to the clinical typing, the data were divided into pooled subgroup and generalized subgroup. Our meta-analysis showed that a significantly increased vitiligo risk was associated with the D/D genotype compared with the I/I + I/D genotype (Odds ratio (OR) 1.79, 95 % confidence interval (95 % CI) 1.35-2.38, P < 0.0001) and the D allele compared with the I allele (OR 1.72, 95 % CI 1.45-2.04, P < 0.00001) in pooled subgroup. In summary, this meta-analysis demonstrated that ACE D/D homozygote and D allele were significantly associated with an increased risk of vitiligo in pooled population. The results indicated that the people with ACE D/D homozygote and D allele may suffer from vitiligo, but of a generalized type. ACE polymorphism might be used as biomarkers for vitiligo risk prediction for pooled vitiligo.
Yajie Lv; Yali Lv; Qiang Li; Wang Lei; Qi Luan; Tianwen Gao
Related Documents :
24072657 - The effect of haplotype variation in the bovine pax6 gene.
23547737 - Correction: differences in gene expression within a striking phenotypic mosaic eucalypt...
24797917 - The serotonin transporter gene polymorphism 5-httlpr moderates the effects of stress on...
24517517 - Tumor necrosis factor haplotype diversity in mestizo and native populations of mexico.
21507037 - Ednrb gene variants and melanoma risk in two southern european populations.
24401187 - Knowledge, group-based medical mistrust, future expectations, and perceived disadvantag...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Archives of dermatological research     Volume:  -     ISSN:  1432-069X     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shannxi, China,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  An Early Social-Psychiatric Work in the GDR.
Next Document:  Astragaloside IV prevents acute kidney injury in two rodent models by inhibiting oxidative stress an...