Document Detail


Association of ACE gene polymorphism and diabetic nephropathy? The Diabetic Nephropathy Study Group.
MedLine Citation:
PMID:  7783416     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In patients with type 1 diabetes an association has been found between an insertion/deletion (I/D) polymorphism in the gene for angiotensin I converting enzyme and the presence of diabetic nephropathy. Our objective was (i) to assess this association in a large cohort of patients with type 1 diabetes and (ii) to examine whether this finding also applies to type 2 diabetes. We examined 247 patients with type 1 diabetes of more than 10 years duration (135 patients > or = 20 years): Nephropathy was present in 114 and absent in 133 patients. Furthermore we separately analyzed 455 patients with type 2 diabetes of more than 10 years duration (158 patients > or = 20 years). Nephropathy was present in 247 and absent in 208 patients. Nephropathy was defined by confirmed presence of albuminuria > 30 mg/day (or > 20 micrograms/min). The I/D polymorphism was analyzed with PCR technique and alleles were visualized on 2% agarose gels after ethidium staining. Allele frequencies in the overall diabetic population did not differ significantly from the normal population. Distribution of genotypes was not significantly different between type 1 patients with and without nephropathy (P = 0.377). Also, no significant difference in genotype distribution was found between type 2 diabetic patients with and without nephropathy (P = 0.948). We conclude that no significant association between I/D polymorphism and nephropathy was demonstrable in either type 1 or type 2 diabetes, despite considerable statistical power of the patient sample and adequate duration of diabetes for nephropathy to become manifest.
Authors:
S Schmidt; N Schöne; E Ritz
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  47     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-07-17     Completed Date:  1995-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1176-81     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Ruperto Carola University Heidelberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Base Sequence
Cohort Studies
DNA / analysis,  genetics
Diabetes Mellitus, Type 1 / enzymology,  genetics*,  pathology
Diabetes Mellitus, Type 2 / genetics*,  metabolism
Diabetic Nephropathies / complications,  enzymology,  genetics*,  pathology
Female
Genotype
Humans
Male
Middle Aged
Molecular Sequence Data
Peptidyl-Dipeptidase A / genetics*,  metabolism
Polymerase Chain Reaction
Polymorphism, Genetic*
Chemical
Reg. No./Substance:
9007-49-2/DNA; EC 3.4.15.1/Peptidyl-Dipeptidase A
Comments/Corrections
Erratum In:
Kidney Int 1995 Sep;48(3):915

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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