| Association of ABO histo-blood group B allele with myocardial infarction. | |
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MedLine Citation:
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PMID: 12786998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate a possible association of ABO blood group alleles with myocardial infarction, a case-control study comprising 177 patients (median age 57.0 years; range 32-72 years) and 89 controls was performed. The distributions of the ABO blood-genotype O1, O2, A1, A2 and B alleles were assessed by analysis of genomic DNA, using the sequence-specific primer-polymerase chain reaction (PCR-SSP) technique to investigate exons VI and VII on chromosome 9. The prevalence of the B allele was 2.5 times higher amongst patients with a history of myocardial infarction than amongst controls (16.3 vs. 6.7%; P = 0.034, Fisher's exact test). There was an association between patients carrying the B allele and myocardial infarction, with an odds ratio (OR) of 2.7 (95% confidence interval 1.1-6.8). The B allele remained an independent risk factor for myocardial infarction (P = 0.038) when classical risk factors were adjusted for by unconditional logistic regression. In conclusion, the ABO blood group B allele was found to be an independent risk factor for myocardial infarction. |
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Authors:
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U E Nydegger; W A Wuillemin; F Julmy; B J Meyer; T P Carrel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics Volume: 30 ISSN: 0960-7420 ISO Abbreviation: Eur. J. Immunogenet. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-05 Completed Date: 2004-02-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9106962 Medline TA: Eur J Immunogenet Country: England |
Other Details:
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Languages: eng Pagination: 201-6 Citation Subset: IM |
Affiliation:
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Clinic for Cardiovascular Surgery, University Hospital/Inselspital, CH-3010 Bern, Switzerland. urs.nydegger@insel.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ABO Blood-Group System
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genetics* Adult Aged Alleles* Case-Control Studies Female Genetic Predisposition to Disease* Humans Male Middle Aged Myocardial Infarction / genetics* Regression Analysis |
| Chemical | |
Reg. No./Substance:
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0/ABO Blood-Group System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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