Document Detail


Association of ABO histo-blood group B allele with myocardial infarction.
MedLine Citation:
PMID:  12786998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate a possible association of ABO blood group alleles with myocardial infarction, a case-control study comprising 177 patients (median age 57.0 years; range 32-72 years) and 89 controls was performed. The distributions of the ABO blood-genotype O1, O2, A1, A2 and B alleles were assessed by analysis of genomic DNA, using the sequence-specific primer-polymerase chain reaction (PCR-SSP) technique to investigate exons VI and VII on chromosome 9. The prevalence of the B allele was 2.5 times higher amongst patients with a history of myocardial infarction than amongst controls (16.3 vs. 6.7%; P = 0.034, Fisher's exact test). There was an association between patients carrying the B allele and myocardial infarction, with an odds ratio (OR) of 2.7 (95% confidence interval 1.1-6.8). The B allele remained an independent risk factor for myocardial infarction (P = 0.038) when classical risk factors were adjusted for by unconditional logistic regression. In conclusion, the ABO blood group B allele was found to be an independent risk factor for myocardial infarction.
Authors:
U E Nydegger; W A Wuillemin; F Julmy; B J Meyer; T P Carrel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics     Volume:  30     ISSN:  0960-7420     ISO Abbreviation:  Eur. J. Immunogenet.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-05     Completed Date:  2004-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9106962     Medline TA:  Eur J Immunogenet     Country:  England    
Other Details:
Languages:  eng     Pagination:  201-6     Citation Subset:  IM    
Affiliation:
Clinic for Cardiovascular Surgery, University Hospital/Inselspital, CH-3010 Bern, Switzerland. urs.nydegger@insel.ch
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MeSH Terms
Descriptor/Qualifier:
ABO Blood-Group System / genetics*
Adult
Aged
Alleles*
Case-Control Studies
Female
Genetic Predisposition to Disease*
Humans
Male
Middle Aged
Myocardial Infarction / genetics*
Regression Analysis
Chemical
Reg. No./Substance:
0/ABO Blood-Group System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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