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Association of A(313)G Glutathione S-transferase P1 germline polymorphism with susceptibility to de novo Myelodysplastic Syndrome.
MedLine Citation:
PMID:  23278642     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Models for the pathogenesis of Myelodysplastic Syndromes (MDS) imply the role of individual genetic variations in genes involved in detoxification mechanisms. GSTP1 enzyme plays a key role in biotransformation of a variety of carcinogens. The corresponding gene is subject to a single-nucleotide polymorphism (A(313)G) leading to abolished enzyme activity. In order to evaluate whether the GSTP1 polymorphism influences MDS susceptibility, we conducted a case-control study comprising 310 de novo patients and 370 healthy controls by using a Real-Time PCR genotyping method. The GSTP1 gene status was also evaluated in relation to patients' characteristics and chromosomal abnormalities. A significantly higher incidence of the GSTP1 variant genotypes was observed in MDS patients compared to the controls (p<0.0001). The results revealed increased frequencies of heterozygotes in patients younger than 60 years old and of homozygotes G/G in older patients (p=0.007). Our results provide evidence for a pathogenetic role of the GSTP1 polymorphism on MDS risk, probably in an age-dependent manner.
Authors:
Sophia Zachaki; Chrysa Stavropoulou; Marina Kalomoiraki; Theodora Koromila; Aggeliki Daraki; Kalliopi N Manola; Ariadni Mavrou; Emmanuel Kanavakis; Gabriel E Pantelias; Constantina Sambani
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-2
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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