| Association of A(313)G Glutathione S-transferase P1 germline polymorphism with susceptibility to de novo Myelodysplastic Syndrome. | |
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MedLine Citation:
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PMID: 23278642 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Models for the pathogenesis of Myelodysplastic Syndromes (MDS) imply the role of individual genetic variations in genes involved in detoxification mechanisms. GSTP1 enzyme plays a key role in biotransformation of a variety of carcinogens. The corresponding gene is subject to a single-nucleotide polymorphism (A(313)G) leading to abolished enzyme activity. In order to evaluate whether the GSTP1 polymorphism influences MDS susceptibility, we conducted a case-control study comprising 310 de novo patients and 370 healthy controls by using a Real-Time PCR genotyping method. The GSTP1 gene status was also evaluated in relation to patients' characteristics and chromosomal abnormalities. A significantly higher incidence of the GSTP1 variant genotypes was observed in MDS patients compared to the controls (p<0.0001). The results revealed increased frequencies of heterozygotes in patients younger than 60 years old and of homozygotes G/G in older patients (p=0.007). Our results provide evidence for a pathogenetic role of the GSTP1 polymorphism on MDS risk, probably in an age-dependent manner. |
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Authors:
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Sophia Zachaki; Chrysa Stavropoulou; Marina Kalomoiraki; Theodora Koromila; Aggeliki Daraki; Kalliopi N Manola; Ariadni Mavrou; Emmanuel Kanavakis; Gabriel E Pantelias; Constantina Sambani |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-2 |
Journal Detail:
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Title: Leukemia & lymphoma Volume: - ISSN: 1029-2403 ISO Abbreviation: Leuk. Lymphoma Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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