| ASSOCIATION OF -55CT POLYMORPHISM OF UCP3 GENE WITH FAT DISTRIBUTION, CARDIOVASCULAR RISK FACTORS AND ADIPOCYTOKINES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. | |
| | |
MedLine Citation:
|
PMID: 21897112 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background and aims: Some studies have pointed to a role of UCP3 in the regulation of fat distribution. The aim of our study was to investigate the influence of -55CT polymorphism of UCP3 gene on fat mass and adipocytokines in naïve patients with diabetes mellitus type 2. Design: A population of 57 patients with diabetes mellitus type 2 and obesity was analyzed in a cross sectional study. Genotype of UCP3 gene -55CT was studied. Results: Forty six patients (80.7%) had the genotype 55CC and 11 patients (19.3%) 55CT. In patients with mutant genotype, fat mass (39.1+/-15.4 kg vs 53.3+/-16.8 kg;p<0.05), weight (92.6+/-17.7 kg vs 106.3+/-17.3 kg:p<0.05), body mass index (36.2+/-6.5 kg/m2 vs 42.8+/-5.2 kg/m2;p<0.05), waist circumference (112.8+/-13.6 cm vs 127.9+/-12.3 cm:p<0.05) and waist to hip ratio (0.96+/-0.1 vs 1.1+/-0.2:p<0.05), C reactive protein (6.1+/-5.1 mg/dl vs 12.4+/-6.1 mg/dl:p<0.05) and leptin (92.8+/-86 ng/ml vs 114+/-89 ng/ml:p<0.05) were higher than patients with wild genotype. Conclusion: In mutant group of - 55 CT UCP3 gene diabetic patients, c reactive protein and fat mass were higher than wild type patients. |
| | |
Authors:
|
D A de Luis; R Aller; O Izaola; M Gonzalez Sagrado; R Conde |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-6 |
Journal Detail:
|
Title: Journal of endocrinological investigation Volume: - ISSN: 1720-8386 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation. Hospital Rio Hortega. University of Valladolid. Valladolid Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: CELL PROLIFERATION PARAMETERS AND APOPTOSIS INDICES IN PITUITARY MACROADENOMAS.
Next Document: METABOLIC CHANGES AFTER A HYPOCALORIC, LOW-GLYCEMIC INDEX DIET IN OBESE CHILDREN.