Document Detail


Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia.
MedLine Citation:
PMID:  19181484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The alpha7 neuronal nicotinic acetylcholine receptor subunit gene (CHRNA7) is localized in a chromosomal region (15q14) linked to schizophrenia in multiple independent studies. CHRNA7 was selected as the best candidate gene in the region for a well-documented endophenotype of schizophrenia, the P50 sensory processing deficit, by genetic linkage and biochemical studies.
METHODS: Subjects included Caucasian-Non Hispanic and African-American case-control subjects collected in Denver, and schizophrenic subjects from families in the NIMH Genetics Initiative on Schizophrenia. Thirty-five single nucleotide polymorphisms (SNPs) in the 5'-upstream regulatory region of CHRNA7 were genotyped for association with schizophrenia, and for smoking in schizophrenia.
RESULTS: The rs3087454 SNP, located at position -1831 bp in the upstream regulatory region of CHRNA7, was significantly associated with schizophrenia in the case-control samples after multiple-testing correction (P=0.0009, African American; P=0.013, Caucasian-Non Hispanic); the association was supported in family members. There was nominal association of this SNP with smoking in schizophrenia.
CONCLUSIONS: The data support association of regulatory region polymorphisms in the CHRNA7 gene with schizophrenia.
Authors:
Sarah H Stephens; Judith Logel; Amanda Barton; Alexis Franks; Jessica Schultz; Margaret Short; Jane Dickenson; Benjamin James; Tasha E Fingerlin; Brandie Wagner; Colin Hodgkinson; Sharon Graw; Randal G Ross; Robert Freedman; Sherry Leonard
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-01-31
Journal Detail:
Title:  Schizophrenia research     Volume:  109     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-06-03     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  102-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
African Americans / genetics
Case-Control Studies
Cell Line
Chromosome Mapping
Chromosomes, Human, Pair 15 / genetics
European Continental Ancestry Group / genetics
Family
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Linkage Disequilibrium
Male
Pedigree
Polymorphism, Single Nucleotide / genetics*
Receptors, Nicotinic / genetics*
Regulatory Sequences, Nucleic Acid / genetics*
Schizophrenia / genetics*
alpha7 Nicotinic Acetylcholine Receptor
Grant Support
ID/Acronym/Agency:
DA09457/DA/NIDA NIH HHS; MH068582/MH/NIMH NIH HHS; MH081177/MH/NIMH NIH HHS; P50 MH044212/MH/NIMH NIH HHS; P50 MH044212-100006/MH/NIMH NIH HHS; R01 DA009457/DA/NIDA NIH HHS; R01 DA009457-11/DA/NIDA NIH HHS; R01 MH081177/MH/NIMH NIH HHS; R01 MH081177-02/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Chrna7 protein, human; 0/Receptors, Nicotinic; 0/alpha7 Nicotinic Acetylcholine Receptor
Comments/Corrections

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