Document Detail


Association of 25-hydroxyvitamin D with blood pressure in predominantly 25-hydroxyvitamin D deficient Hispanic and African Americans.
MedLine Citation:
PMID:  19444222     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Several observational studies have recently suggested an inverse association of circulating levels of vitamin D with blood pressure. These findings have been based mainly on Caucasian populations; whether this association also exists among Hispanic and African Americans has yet to be definitively determined. This study investigates the association of 25-hydroxyvitamin D (25[OH]D) with blood pressure in Hispanic and African Americans.
METHODS: The data source for this study is the Insulin Resistance Atherosclerosis Family Study (IRASFS), which consists of Hispanic- and African-American families from three US recruitment centers (n =1,334). A variance components model was used to analyze the association of plasma 25[OH]D levels with blood pressure.
RESULTS: An inverse association was found between 25[OH]D and both systolic (beta for 10 ng/ml difference = -2.05; P < 0.01) and diastolic (beta for 10 ng/ml difference = -1.35; P < 0.001) blood pressure in all populations combined, after adjusting for age, sex, ethnicity, and season of blood draw. Further adjustment for body mass index (BMI) weakened this association (beta for 10 ng/ml difference = -0.94; P = 0.14 and beta for 10 ng/ml difference = -0.64; P = 0.09, respectively).
CONCLUSIONS: 25[OH]D levels are significantly inversely associated with blood pressure in Hispanic and African Americans from the IRASFS. However, this association was not significant after adjustment for BMI. Further research is needed to determine the role of BMI in this association. Large, well-designed prospective studies of the effect of vitamin D supplementation on blood pressure may be warranted.
Authors:
Kimberly J Schmitz; Halcyon G Skinner; Leonelo E Bautista; Tasha E Fingerlin; Carl D Langefeld; Pamela J Hicks; Steven M Haffner; Michael Bryer-Ash; Lynne E Wagenknecht; Donald W Bowden; Jill M Norris; Corinne D Engelman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-05-14
Journal Detail:
Title:  American journal of hypertension     Volume:  22     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-29     Completed Date:  2009-10-05     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  867-70     Citation Subset:  IM    
Affiliation:
Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
African Americans
Age Factors
Aged
Aged, 80 and over
Atherosclerosis / blood,  epidemiology
Blood Pressure / physiology*
Body Mass Index
Female
Hispanic Americans
Humans
Insulin Resistance
Male
Middle Aged
Motor Activity / physiology
Phenotype
Rural Population
Seasons
Smoking / adverse effects,  epidemiology
United States / epidemiology
Urban Population
Vitamin D / blood*
Vitamin D Deficiency / blood*,  epidemiology*
Young Adult
Grant Support
ID/Acronym/Agency:
HL060894/HL/NHLBI NIH HHS; HL060919/HL/NHLBI NIH HHS; HL060931/HL/NHLBI NIH HHS; HL060944/HL/NHLBI NIH HHS; HL061019/HL/NHLBI NIH HHS; HL061210/HL/NHLBI NIH HHS; M01 RR000069-37/RR/NCRR NIH HHS; M01RR00069/RR/NCRR NIH HHS; R01 DK029867/DK/NIDDK NIH HHS; R01 HL060894-01A1/HL/NHLBI NIH HHS; R01 HL060919-01A1/HL/NHLBI NIH HHS; R01 HL060931-01A1/HL/NHLBI NIH HHS; R01 HL060944-01A1/HL/NHLBI NIH HHS; R01 HL061019-01A1/HL/NHLBI NIH HHS; R01 HL061210-01A1/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D
Comments/Corrections
Comment In:
Am J Hypertens. 2009 Aug;22(8):816   [PMID:  19638953 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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