Document Detail

Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters.
MedLine Citation:
PMID:  23042450     Owner:  NLM     Status:  MEDLINE    
Vitamin D levels have been linked to various health outcomes including reproductive disorders. The purpose of this study was to explore the association between serum vitamin D level (25-hydroxy-vitamin D, or 25OHD) and semen and hormonal parameters. This is a cross-sectional study that included 170 healthy men recruited for the study of spermatogenesis from the general population. Men completed general and reproductive health questionnaires, and donated blood and semen samples. The main measures were hormonal (total and free testosterone, sex hormone-binding globulin, estradiol, follicle-stimulating hormone and luteinizing hormone) and semen parameters, adjusted (n=147) for age, body mass index (BMI), season, alcohol intake and smoking, in relation to categories of vitamin D levels, determined a priori. The mean age of the study population was 29.0±8.5 years and mean BMI was 24.3±3.2 kg m(-2). The mean 25OHD was 34.1±15.06 ng ml(-1). BMI showed a negative association with 25OHD. Sperm concentration, sperm progressive motility, sperm morphology, and total progressively motile sperm count were lower in men with '25OHD≥50 ng ml(-1)' when compared to men with '20 ng ml(-1)≤25OHD<50 ng ml(-1)'. Total sperm count and total progressive motile sperm count were lower in men with '25OHD<20 ng ml(-1)' when compared to men with '20 ng ml(-1)≤25OHD<50 ng ml(-1)'. The adjusted means of various hormonal parameters did not show statistical difference in the different categories of 25OHD. In conclusion, serum vitamin D levels at high and low levels can be negatively associated with semen parameters.
Ahmad O Hammoud; A Wayne Meikle; C Matthew Peterson; Joseph Stanford; Mark Gibson; Douglas T Carrell
Publication Detail:
Type:  Journal Article     Date:  2012-10-08
Journal Detail:
Title:  Asian journal of andrology     Volume:  14     ISSN:  1745-7262     ISO Abbreviation:  Asian J. Androl.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-07     Completed Date:  2013-04-22     Revised Date:  2013-09-17    
Medline Journal Info:
Nlm Unique ID:  100942132     Medline TA:  Asian J Androl     Country:  China    
Other Details:
Languages:  eng     Pagination:  855-9     Citation Subset:  IM    
Division of Reproductive Endocrinology and Infertility, University of Utah, Salt Lake City, UT 84108, USA.
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MeSH Terms
Body Mass Index
Cross-Sectional Studies
Estradiol / blood
Follicle Stimulating Hormone / blood
Luteinizing Hormone / blood
Middle Aged
Semen Analysis*
Sex Hormone-Binding Globulin
Sperm Motility / drug effects
Testosterone / blood
Vitamin D / analogs & derivatives*,  blood
Reg. No./Substance:
0/Sex Hormone-Binding Globulin; 1406-16-2/Vitamin D; 50-28-2/Estradiol; 58-22-0/Testosterone; 64719-49-9/25-hydroxyvitamin D; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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