| Association of 14-bp insertion/deletion polymorphism of HLA-G gene with unexplained recurrent spontaneous abortion: a meta-analysis. | |
| | |
MedLine Citation:
|
PMID: 23330721 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
A meta-analysis was performed to assess the association of the human leukocyte antigen-G (HLA-G) 14 bp insertion (ins)/deletion (del) polymorphism with unexplained recurrent spontaneous abortions (URSA). The fixed or random effect pooled measure was selected based on the homogeneity test among studies that was evaluated with I(2) . Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of the association. In this meta-analysis, 14 studies with 1464 cases and 1247 controls corresponded to the inclusion criteria were included. Significant associations between 14 bp ins/del polymorphism and risk of URSA were observed in both dominant [random effect model (REM) OR = 1.469, 95% CI = 1.127-1.914] and codominant (REM OR = 1.195, 95% CI = 1.005-1.420) models. After excluding two articles that deviated from Hardy-Weinberg equilibrium in cases and sensitivity analysis, significant associations were also observed in dominant [fixed effect model (FEM) OR = 1.224, 95% CI = 1.020-1.470] and codominant (FEM OR = 1.158, 95% CI = 1.028-1.305) models. This meta-analysis suggests that the 14 bp ins HLA-G allele is associated with increased risk of URSA. The results are of importance to the clinical practice of URSA and infertility. |
| | |
Authors:
|
X Wang; W Jiang; D Zhang |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Tissue antigens Volume: 81 ISSN: 1399-0039 ISO Abbreviation: Tissue Antigens Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: England |
Other Details:
|
Languages: eng Pagination: 108-15 Citation Subset: IM |
Copyright Information:
|
© 2013 John Wiley & Sons A/S. |
Affiliation:
|
Department of Public Health, Qingdao University Medical College, 266021, Qingdao, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: HLA class I associations with rates of HIV-1 seroconversion and disease progression in the Pumwani S...
Next Document: Identification of a novel HLA-A allele, A*24:128 in a Chinese individual.