Document Detail

Association of 14-3-3 epsilon gene haplotype with completed suicide in Japanese.
MedLine Citation:
PMID:  15838597     Owner:  NLM     Status:  MEDLINE    
Genetic factors have been suggested to be involved in suicide. Although some genetic factors, such as serotonergic transduction, have been associated with suicide, the results are inconsistent. There is a possibility that various signaling anomalies are involved in the biological vulnerability to suicide. We carried out a genome-wide gene-expression study in the brains of suicide victims using DNA microarrays;14-3-3 epsilon, which is related to neurogenesis, was one of the genes upregulated in the brains of suicide victims in the microarray analysis. This was confirmed by Western blot analysis. To examine the possibility of the involvement of 14-3-3 epsilon in the pathogenesis of suicide, we investigated the association of the 14-3-3 epsilon gene and completed suicide. We used three high-frequency SNPs (rs1532976, rs3752826, and rs9393) and found a significant association of two alleles (rs1532976 and rs3752826) with completed suicide (p < 0.05). Moreover, the distribution of haplotype revealed a more significant difference between completed suicide and controls (p=0.0005). This finding suggests that 14-3-3 epsilon is a potential suicide susceptibility gene and implies that dysregulation of neurogenesis may be involved in suicide.
Masaya Yanagi; Osamu Shirakawa; Noboru Kitamura; Kenji Okamura; Kaoru Sakurai; Naoki Nishiguchi; Takeshi Hashimoto; Hideyuki Nushida; Yasuhiro Ueno; Daiji Kanbe; Meiko Kawamura; Kazuaki Araki; Hiroyuki Nawa; Kiyoshi Maeda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-19
Journal Detail:
Title:  Journal of human genetics     Volume:  50     ISSN:  1434-5161     ISO Abbreviation:  J. Hum. Genet.     Publication Date:  2005  
Date Detail:
Created Date:  2005-05-06     Completed Date:  2005-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9808008     Medline TA:  J Hum Genet     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  210-6     Citation Subset:  IM    
Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Faculty of Medical Sciences, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho Chuo-Ku, Kobe 650-0017, Japan.
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MeSH Terms
14-3-3 Proteins / genetics*
Gene Expression Profiling
Genetic Predisposition to Disease*
Haplotypes / genetics*
Middle Aged
Oligonucleotide Array Sequence Analysis
Polymorphism, Single Nucleotide / genetics*
Reg. No./Substance:
0/14-3-3 Proteins

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