| Association of δ¹³C in fingerstick blood with added-sugar and sugar-sweetened beverage intake. | |
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MedLine Citation:
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PMID: 21616200 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A reliance on self-reported dietary intake measures is a common research limitation, thus the need for dietary biomarkers. Added-sugar intake may play a role in the development and progression of obesity and related comorbidities; common sweeteners include corn and sugar cane derivatives. These plants contain a high amount of ¹³C, a naturally occurring stable carbon isotope. Consumption of these sweeteners, of which sugar-sweetened beverages are the primary dietary source, might be reflected in the δ¹³C value of blood. Fingerstick blood represents an ideal substrate for bioassay because of its ease of acquisition. The objective of this investigation was to determine if the δ¹³C value of fingerstick blood is a potential biomarker of added-sugar and sugar-sweetened beverage intake. Individuals aged 21 years and older (n = 60) were recruited to attend three laboratory visits; assessments completed at each visit depended upon a randomly assigned sequence (sequence one or two). The initial visit included assessment of height, weight, and dietary intake (sequence one: beverage intake questionnaire, sequence two: 4-day food intake record). Sequence one participants completed a food intake record at visit two, and nonfasting blood samples were obtained via routine fingersticks at visits one and three. Sequence two participants completed a beverage intake questionnaire at visit two, and provided fingerstick blood samples at visits two and three. Samples were analyzed for δ¹³C value using natural abundance stable isotope mass spectrometry. δ¹³C value was compared to dietary outcomes in all participants, as well as among those in the highest and lowest tertile of added-sugar intake. Reported mean added-sugar consumption was 66 ± 5 g/day, and sugar-sweetened beverage consumption was 330 ± 53 g/day and 134 ± 25 kcal/day. Mean fingerstick δ¹³C value was -19.94‰ ± 0.10‰, which differed by body mass index status. δ¹³C value was associated (all P < 0.05) with intake of total added sugars (g, r = 0.37; kcal, r = 0.37), soft drinks (g, r = 0.26; kcal, r = 0.27), and total sugar-sweetened beverage (g, r = 0.28; kcal, r = 0.35). The δ¹³C value in the lowest and the highest added-sugar intake tertiles were significantly different (mean difference = -0.48‰; P = 0.028). Although there are several potential dietary sources for blood carbon, the δ¹³C value of fingerstick blood shows promise as a noninvasive biomarker of added-sugar and sugar-sweetened beverage intake based on these findings. |
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Authors:
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Brenda M Davy; A Hope Jahren; Valisa E Hedrick; Dana L Comber |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of the American Dietetic Association Volume: 111 ISSN: 1878-3570 ISO Abbreviation: J Am Diet Assoc Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-27 Completed Date: 2011-07-21 Revised Date: 2013-05-24 |
Medline Journal Info:
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Nlm Unique ID: 7503061 Medline TA: J Am Diet Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 874-8 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 American Dietetic Association. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Human Nutrition, Foods and Exercise, Virginia Tech, Blacksburg, Va, USA. bdavy@vt.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Beverages* / statistics & numerical data Biological Markers / blood Carbon Isotopes / blood* Diet Records Dietary Sucrose / administration & dosage*, blood* Female Humans Male Middle Aged Obesity / blood, etiology, prevention & control Questionnaires Self Disclosure Sweetening Agents / administration & dosage*, metabolism Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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K01 DK075424-04/DK/NIDDK NIH HHS; K01 DK075424-05/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Carbon Isotopes; 0/Dietary Sucrose; 0/Sweetening Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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