Document Detail


Association of δ¹³C in fingerstick blood with added-sugar and sugar-sweetened beverage intake.
MedLine Citation:
PMID:  21616200     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A reliance on self-reported dietary intake measures is a common research limitation, thus the need for dietary biomarkers. Added-sugar intake may play a role in the development and progression of obesity and related comorbidities; common sweeteners include corn and sugar cane derivatives. These plants contain a high amount of ¹³C, a naturally occurring stable carbon isotope. Consumption of these sweeteners, of which sugar-sweetened beverages are the primary dietary source, might be reflected in the δ¹³C value of blood. Fingerstick blood represents an ideal substrate for bioassay because of its ease of acquisition. The objective of this investigation was to determine if the δ¹³C value of fingerstick blood is a potential biomarker of added-sugar and sugar-sweetened beverage intake. Individuals aged 21 years and older (n = 60) were recruited to attend three laboratory visits; assessments completed at each visit depended upon a randomly assigned sequence (sequence one or two). The initial visit included assessment of height, weight, and dietary intake (sequence one: beverage intake questionnaire, sequence two: 4-day food intake record). Sequence one participants completed a food intake record at visit two, and nonfasting blood samples were obtained via routine fingersticks at visits one and three. Sequence two participants completed a beverage intake questionnaire at visit two, and provided fingerstick blood samples at visits two and three. Samples were analyzed for δ¹³C value using natural abundance stable isotope mass spectrometry. δ¹³C value was compared to dietary outcomes in all participants, as well as among those in the highest and lowest tertile of added-sugar intake. Reported mean added-sugar consumption was 66 ± 5 g/day, and sugar-sweetened beverage consumption was 330 ± 53 g/day and 134 ± 25 kcal/day. Mean fingerstick δ¹³C value was -19.94‰ ± 0.10‰, which differed by body mass index status. δ¹³C value was associated (all P < 0.05) with intake of total added sugars (g, r = 0.37; kcal, r = 0.37), soft drinks (g, r = 0.26; kcal, r = 0.27), and total sugar-sweetened beverage (g, r = 0.28; kcal, r = 0.35). The δ¹³C value in the lowest and the highest added-sugar intake tertiles were significantly different (mean difference = -0.48‰; P = 0.028). Although there are several potential dietary sources for blood carbon, the δ¹³C value of fingerstick blood shows promise as a noninvasive biomarker of added-sugar and sugar-sweetened beverage intake based on these findings.
Authors:
Brenda M Davy; A Hope Jahren; Valisa E Hedrick; Dana L Comber
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of the American Dietetic Association     Volume:  111     ISSN:  1878-3570     ISO Abbreviation:  J Am Diet Assoc     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-27     Completed Date:  2011-07-21     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  7503061     Medline TA:  J Am Diet Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  874-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 American Dietetic Association. Published by Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Beverages* / statistics & numerical data
Biological Markers / blood
Carbon Isotopes / blood*
Diet Records
Dietary Sucrose / administration & dosage*,  blood*
Female
Humans
Male
Middle Aged
Obesity / blood,  etiology,  prevention & control
Questionnaires
Self Disclosure
Sweetening Agents / administration & dosage*,  metabolism
Young Adult
Grant Support
ID/Acronym/Agency:
K01 DK075424/DK/NIDDK NIH HHS; K01 DK075424-04/DK/NIDDK NIH HHS; K01 DK075424-05/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Carbon Isotopes; 0/Dietary Sucrose; 0/Sweetening Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Signaling Proteins that Influence Energy Intake may Affect Unintentional Weight Loss in Elderly Pers...
Next Document:  Demographic and financial characteristics of school districts with low and high à la Carte sales in...