| Associated morbidities in children with sickle-cell anaemia presenting with severe anaemia in a malarious area. | |
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MedLine Citation:
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PMID: 11205596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A prospective study of 104 consecutive cases of patients with sickle-cell anaemia (SCA) presenting with severe anaemia (packed cell volume < or = 15%) was carried out in the Children's Emergency Ward of the University College Hospital, Ibadan, in 1991. The patients were classified according to the type of anaemic crisis, by physical findings, serum bilirubin and reticulocyte counts. Other investigations included a blood film for malaria parasites, blood culture, radiological investigation and lumbar puncture when necessary. The most common problems associated with SCA patients in anaemic crisis were malaria and bacterial infections--68 (66%) and 18 (17.3%) of cases, respectively. Acute chest syndrome was significantly more frequent in patients with hyperhaemolytic and acute splenic sequestration crisis compared with aplastic crisis (P < 0.05). Conjugated hyperbilirubinaemia was also significantly more frequent among patients with hyperhaemolytic crisis compared with all other anaemic crises (chi2 = 13.18, P = 0.001). The overall case fatality was 86.5/1,000 SCAs, with no fatalities in those with aplastic crisis. There were complications in six of the nine mortalities. Co-existing bacterial infections and conjugated hyperbilirubinaemia were associated with increased morbidity and mortality in patients with anaemic crisis. Patients with SCA crisis should have early evaluation and prompt treatment for associated infections. |
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Authors:
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J P Ambe; J O Fatunde; O O Sodeinde |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Tropical doctor Volume: 31 ISSN: 0049-4755 ISO Abbreviation: Trop Doct Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-02-05 Completed Date: 2001-05-17 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 1301706 Medline TA: Trop Doct Country: England |
Other Details:
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Languages: eng Pagination: 26-7 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, College of Medical Sciences, University of Maiduguri, Borno State, Nigeria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anemia, Sickle Cell / epidemiology*, mortality Bacterial Infections / epidemiology*, mortality Child Child, Preschool Comorbidity Female Humans Infant Malaria / epidemiology*, mortality Male Nigeria / epidemiology Prospective Studies Severity of Illness Index |
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