Document Detail

Associated morbidities in children with sickle-cell anaemia presenting with severe anaemia in a malarious area.
MedLine Citation:
PMID:  11205596     Owner:  NLM     Status:  MEDLINE    
A prospective study of 104 consecutive cases of patients with sickle-cell anaemia (SCA) presenting with severe anaemia (packed cell volume < or = 15%) was carried out in the Children's Emergency Ward of the University College Hospital, Ibadan, in 1991. The patients were classified according to the type of anaemic crisis, by physical findings, serum bilirubin and reticulocyte counts. Other investigations included a blood film for malaria parasites, blood culture, radiological investigation and lumbar puncture when necessary. The most common problems associated with SCA patients in anaemic crisis were malaria and bacterial infections--68 (66%) and 18 (17.3%) of cases, respectively. Acute chest syndrome was significantly more frequent in patients with hyperhaemolytic and acute splenic sequestration crisis compared with aplastic crisis (P < 0.05). Conjugated hyperbilirubinaemia was also significantly more frequent among patients with hyperhaemolytic crisis compared with all other anaemic crises (chi2 = 13.18, P = 0.001). The overall case fatality was 86.5/1,000 SCAs, with no fatalities in those with aplastic crisis. There were complications in six of the nine mortalities. Co-existing bacterial infections and conjugated hyperbilirubinaemia were associated with increased morbidity and mortality in patients with anaemic crisis. Patients with SCA crisis should have early evaluation and prompt treatment for associated infections.
J P Ambe; J O Fatunde; O O Sodeinde
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tropical doctor     Volume:  31     ISSN:  0049-4755     ISO Abbreviation:  Trop Doct     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-05     Completed Date:  2001-05-17     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  1301706     Medline TA:  Trop Doct     Country:  England    
Other Details:
Languages:  eng     Pagination:  26-7     Citation Subset:  IM    
Department of Paediatrics, College of Medical Sciences, University of Maiduguri, Borno State, Nigeria.
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MeSH Terms
Anemia, Sickle Cell / epidemiology*,  mortality
Bacterial Infections / epidemiology*,  mortality
Child, Preschool
Malaria / epidemiology*,  mortality
Nigeria / epidemiology
Prospective Studies
Severity of Illness Index

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