Document Detail


Associated malformations in infants and fetuses with upper or lower neural tube defects.
MedLine Citation:
PMID:  9562677     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The paper describes associated malformations in infants born with neural tube defects (N = 3,809) from three large malformation registers and in fetuses aborted because of a diagnosed neural tube defect (N = 748) from two of the registers. In infants, upper spina bifida and encephalocele are more often associated with non-neural malformations than anencephaly or lower spina bifida. Aborted fetuses with spina bifida or encephalocele have associated malformations registered more often than infants with those neural tube defects, but the opposite is true for anencephaly. The degree of detail of the investigation of an aborted specimen or a perinatally dead infant will contribute to such differences but they can also depend on the fact that prenatal detection may be facilitated by the simultaneous presence of other malformations like body wall defects. Also, fetuses with many malformations may be more prone to abort spontaneously late in pregnancy. Variable prenatal diagnosis may, therefore, explain population differences in the pattern of associated malformations. The type of associated malformation differs with the level of the neural tube defect: this could be due to different causal mechanisms or be a question of cranio-caudal level and/or timing. For limb reduction defects, however, we did not find any association between upper limb and upper neural tube defects or lower limb and lower neural tube defects. These findings together with other epidemiological data support the idea that upper and lower neural tube defects may have different significance in epidemiological studies and should be treated separately.
Authors:
B Kälién; E Robert; J Harris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Teratology     Volume:  57     ISSN:  0040-3709     ISO Abbreviation:  Teratology     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-06-18     Completed Date:  1998-06-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0153257     Medline TA:  Teratology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  56-63     Citation Subset:  IM    
Affiliation:
Tornblad Institute, University of Lund, Sweden. embryol@embryol.lu.se
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / epidemiology*,  ethnology
Abortion, Induced
California / epidemiology
Chromosome Aberrations / epidemiology,  ethnology
Chromosome Disorders
Female
Fetus / abnormalities
France / epidemiology
Humans
Infant, Newborn
Male
Neural Tube Defects / epidemiology*,  ethnology
Odds Ratio
Pregnancy
Registries
Risk Factors
Sweden / epidemiology
Syndrome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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